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Literature summary for 3.5.1.5 extracted from

  • Khan, K.M.; Naz, F.; Taha, M.; Khan, A.; Perveen, S.; Choudhary, M.I.; Voelter, W.
    Synthesis and in vitro urease inhibitory activity of N,N'-disubstituted thioureas (2014), Eur. J. Med. Chem., 74, 314-323.
    View publication on PubMed
Search for more literature for 3.5.1.5

Inhibitors

Inhibitors Comment Organism Structure
1,3-bis(3-chlorophenyl)thiourea
-
 Canavalia ensiformis
1-(2,4-difluorophenyl)-3-phenylthiourea
-
 Canavalia ensiformis
1-(2,5-dimethoxyphenyl)-3-phenylthiourea
-
 Canavalia ensiformis
1-(2-chlorophenyl)-3-(3-chlorophenyl)thiourea
-
 Canavalia ensiformis
1-(2-chloropyridin-3-yl)-3-phenylthiourea
-
 Canavalia ensiformis
1-(3,5-dichloropyridin-2-yl)-3-phenylthiourea
-
 Canavalia ensiformis
1-(3-bromophenyl)-3-phenylthiourea
-
 Canavalia ensiformis
1-(3-chlorophenyl)-3-(2,3-dichlorophenyl)thiourea
-
 Canavalia ensiformis
1-(3-chlorophenyl)-3-(2,4-dichlorophenyl)thiourea
-
 Canavalia ensiformis
1-(3-chlorophenyl)-3-(2,4-dimethylphenyl)thiourea
-
 Canavalia ensiformis
1-(3-chlorophenyl)-3-(2,5-dimethylphenyl)thiourea
-
 Canavalia ensiformis
1-(3-chlorophenyl)-3-(2,6-dichlorophenyl)thiourea
-
 Canavalia ensiformis
1-(3-chlorophenyl)-3-(2,6-dimethylphenyl)thiourea
-
 Canavalia ensiformis
1-(3-chlorophenyl)-3-(2-chloropyridin-3-yl)thiourea
-
 Canavalia ensiformis
1-(3-chlorophenyl)-3-(2-methoxyphenyl)thiourea
-
 Canavalia ensiformis
1-(3-chlorophenyl)-3-(3,4-dichlorophenyl)thiourea
-
 Canavalia ensiformis
1-(3-chlorophenyl)-3-(3,4-difluorophenyl)thiourea
-
 Canavalia ensiformis
1-(3-chlorophenyl)-3-(3-methoxyphenyl)thiourea
-
 Canavalia ensiformis
1-(3-chlorophenyl)-3-(3-methylpyridin-2-yl)thiourea
-
 Canavalia ensiformis
1-(3-chlorophenyl)-3-(4-chlorophenyl)thiourea
-
 Canavalia ensiformis
1-(3-chlorophenyl)-3-(4-fluorophenyl)thiourea
-
 Canavalia ensiformis
1-(3-chlorophenyl)-3-(4-methoxyphenyl)thiourea
-
 Canavalia ensiformis
1-(3-chlorophenyl)-3-(m-tolyl)thiourea
-
 Canavalia ensiformis
1-(3-chlorophenyl)-3-(o-tolyl)thiourea
-
 Canavalia ensiformis
1-(3-chlorophenyl)-3-(p-tolyl)thiourea
-
 Canavalia ensiformis
1-(3-chlorophenyl)-3-(pyridin-3-yl)thiourea
-
 Canavalia ensiformis
1-(3-chlorophenyl)-3-(pyridin-3-ylmethyl)thiourea
-
 Canavalia ensiformis
1-(3-chlorophenyl)-3-(pyridin-4-ylmethyl)thiourea
-
 Canavalia ensiformis
1-(3-methylpyridin-2-yl)-3-phenylthiourea
-
 Canavalia ensiformis
1-(4-bromophenyl)-3-phenylthiourea
-
 Canavalia ensiformis
1-(5-bromo-6-methylpyridin-2-yl)-3-phenylthiourea
-
 Canavalia ensiformis
1-(5-chloro-2-methylphenyl)-3-(3-chlorophenyl)thiourea
-
 Canavalia ensiformis
1-(furan-2-ylmethyl)-3-phenylthiourea
-
 Canavalia ensiformis
1-phenyl-3-(pyridin-2-yl)thiourea
-
 Canavalia ensiformis
1-phenyl-3-(pyridin-3-yl)thiourea
-
 Canavalia ensiformis
1-phenyl-3-(pyridin-3-ylmethyl)thiourea
-
 Canavalia ensiformis
1-phenyl-3-(pyridin-4-yl)thiourea
-
 Canavalia ensiformis
1-phenyl-3-(pyridin-4-ylmethyl)thiourea
-
 Canavalia ensiformis
additional information synthesis and in vitro urease inhibitory activity of N,N'-disubstituted thioureas, overview. no inhibition by 24 and 36 Canavalia ensiformis
N-(3-chlorophenyl)-N'-(4-methoxyphenyl)thiourea
-
 Canavalia ensiformis
Thiourea competitive inhibition Canavalia ensiformis

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information steady-state kinetics analysis Canavalia ensiformis

Organism

Organism UniProt Comment Textmining
Canavalia ensiformis
-
-
-

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 assay at Canavalia ensiformis

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.8
-
 assay at Canavalia ensiformis

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
 additional information inhibition kinetics analysis Canavalia ensiformis
0.0086
-
 1-phenyl-3-(pyridin-3-yl)thiourea pH 6.8, 30°C Canavalia ensiformis
0.0117
-
 1-(3-chlorophenyl)-3-(3,4-dichlorophenyl)thiourea pH 6.8, 30°C Canavalia ensiformis
0.0121
-
 1-(3-chlorophenyl)-3-(p-tolyl)thiourea pH 6.8, 30°C Canavalia ensiformis
0.0156
-
 1-(3-bromophenyl)-3-phenylthiourea pH 6.8, 30°C Canavalia ensiformis
0.0157
-
 1-(3-chlorophenyl)-3-(m-tolyl)thiourea pH 6.8, 30°C Canavalia ensiformis
0.0168
-
 1-(3-chlorophenyl)-3-(4-fluorophenyl)thiourea pH 6.8, 30°C Canavalia ensiformis
0.0181
-
 1,3-bis(3-chlorophenyl)thiourea pH 6.8, 30°C Canavalia ensiformis
0.0181
-
 1-(3-chlorophenyl)-3-(4-chlorophenyl)thiourea pH 6.8, 30°C Canavalia ensiformis
0.0185
-
 1-(5-chloro-2-methylphenyl)-3-(3-chlorophenyl)thiourea pH 6.8, 30°C Canavalia ensiformis
0.0193
-
 1-(3-chlorophenyl)-3-(2,5-dimethylphenyl)thiourea pH 6.8, 30°C Canavalia ensiformis

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00843
-
 pH 6.8, 30°C Canavalia ensiformis 1-phenyl-3-(pyridin-3-yl)thiourea
0.01103
-
 pH 6.8, 30°C Canavalia ensiformis 1-(3-chlorophenyl)-3-(3,4-dichlorophenyl)thiourea
0.01503
-
 pH 6.8, 30°C Canavalia ensiformis 1-(3-chlorophenyl)-3-(m-tolyl)thiourea
0.0159
-
 pH 6.8, 30°C Canavalia ensiformis 1-(3-chlorophenyl)-3-(3-methylpyridin-2-yl)thiourea
0.0163
-
 pH 6.8, 30°C Canavalia ensiformis 1-(3-chlorophenyl)-3-(3,4-difluorophenyl)thiourea
0.0183
-
 pH 6.8, 30°C Canavalia ensiformis 1-(3-bromophenyl)-3-phenylthiourea
0.0186
-
 pH 6.8, 30°C Canavalia ensiformis 1-(3-chlorophenyl)-3-(p-tolyl)thiourea
0.0191
-
 pH 6.8, 30°C Canavalia ensiformis 1-(3-chlorophenyl)-3-(4-fluorophenyl)thiourea
0.02006
-
 pH 6.8, 30°C Canavalia ensiformis 1-(3-chlorophenyl)-3-(2-methoxyphenyl)thiourea
0.0201
-
 pH 6.8, 30°C Canavalia ensiformis 1-(5-chloro-2-methylphenyl)-3-(3-chlorophenyl)thiourea
0.02033
-
 pH 6.8, 30°C Canavalia ensiformis 1-(3-chlorophenyl)-3-(4-chlorophenyl)thiourea
0.0209
-
 pH 6.8, 30°C Canavalia ensiformis 1-(3-chlorophenyl)-3-(2,5-dimethylphenyl)thiourea
0.021
-
 pH and temperature not specified in the publication Canavalia ensiformis Thiourea
0.022
-
 pH 6.8, 30°C Canavalia ensiformis 1-(2-chlorophenyl)-3-(3-chlorophenyl)thiourea
0.0227
-
 pH 6.8, 30°C Canavalia ensiformis 1-(3-chlorophenyl)-3-(pyridin-4-ylmethyl)thiourea
0.02303
-
 pH 6.8, 30°C Canavalia ensiformis 1-(3-chlorophenyl)-3-(pyridin-3-ylmethyl)thiourea
0.02336
-
 pH 6.8, 30°C Canavalia ensiformis 1-phenyl-3-(pyridin-2-yl)thiourea
0.0241
-
 pH 6.8, 30°C Canavalia ensiformis 1-(3-chlorophenyl)-3-(2,4-dimethylphenyl)thiourea
0.0243
-
 pH 6.8, 30°C Canavalia ensiformis 1-(2,4-difluorophenyl)-3-phenylthiourea
0.02446
-
 pH 6.8, 30°C Canavalia ensiformis 1-(3-chlorophenyl)-3-(3-methoxyphenyl)thiourea
0.02446
-
 pH 6.8, 30°C Canavalia ensiformis 1-(3-chlorophenyl)-3-(pyridin-3-yl)thiourea
0.0253
-
 pH 6.8, 30°C Canavalia ensiformis 1-(3-methylpyridin-2-yl)-3-phenylthiourea
0.0271
-
 pH 6.8, 30°C Canavalia ensiformis 1-(3-chlorophenyl)-3-(2,3-dichlorophenyl)thiourea
0.0274
-
 pH 6.8, 30°C Canavalia ensiformis 1-(3-chlorophenyl)-3-(2,6-dimethylphenyl)thiourea
0.02956
-
 pH 6.8, 30°C Canavalia ensiformis 1-(3-chlorophenyl)-3-(4-methoxyphenyl)thiourea
0.02993
-
 pH 6.8, 30°C Canavalia ensiformis 1-(2,5-dimethoxyphenyl)-3-phenylthiourea
0.03236
-
 pH 6.8, 30°C Canavalia ensiformis 1-(furan-2-ylmethyl)-3-phenylthiourea
0.0326
-
 pH 6.8, 30°C Canavalia ensiformis 1-phenyl-3-(pyridin-4-ylmethyl)thiourea
0.0335
-
 pH 6.8, 30°C Canavalia ensiformis 1-phenyl-3-(pyridin-3-ylmethyl)thiourea
0.03426
-
 pH 6.8, 30°C Canavalia ensiformis 1-(4-bromophenyl)-3-phenylthiourea
0.0344
-
 pH 6.8, 30°C Canavalia ensiformis 1-(3-chlorophenyl)-3-(o-tolyl)thiourea
0.03703
-
 pH 6.8, 30°C Canavalia ensiformis 1-(3,5-dichloropyridin-2-yl)-3-phenylthiourea
0.04096
-
 pH 6.8, 30°C Canavalia ensiformis 1-(3-chlorophenyl)-3-(2,6-dichlorophenyl)thiourea
0.0422
-
 pH 6.8, 30°C Canavalia ensiformis 1-(3-chlorophenyl)-3-(2,4-dichlorophenyl)thiourea
0.04393
-
 pH 6.8, 30°C Canavalia ensiformis 1-phenyl-3-(pyridin-4-yl)thiourea
0.0827
-
 pH 6.8, 30°C Canavalia ensiformis 1-(5-bromo-6-methylpyridin-2-yl)-3-phenylthiourea