Literature summary for 3.5.1.5 extracted from

Li, H.Q.; Xiao, Z.P.; Yin-Luo, Z.P.; Yan, T.; Lv, P.C.; Zhu, H.L.
Amines and oximes derived from deoxybenzoins as Helicobacter pylori urease inhibitors (2009), Eur. J. Med. Chem., 44, 2246-2251.

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Inhibitors

Inhibitors	Comment	Organism	Structure
1-(2,4-dihydroxyphenyl)-2-(4-fluorophenyl)ethanone oxime	-	Helicobacter pylori
1-(2,4-dihydroxyphenyl)-2-(4-methoxyphenyl)ethanone oxime	-	Helicobacter pylori
1-(2-hydroxy-4,6-dimethoxyphenyl)-2-(4-methoxyphenyl)ethanone oxime	-	Helicobacter pylori
1-(3,4-dihydroxyphenyl)-2-(4-hydroxyphenyl)ethanone oxime	-	Helicobacter pylori
2-(1-amino-2-(4-hydroxyphenyl)ethyl)-4-methoxybenzene-1,3,5-triol	-	Helicobacter pylori
2-(1-amino-2-(4-hydroxyphenyl)ethyl)benzene-1,3,5-triol	-	Helicobacter pylori
2-(4-fluorophenyl)-1-(2,3,4-trihydroxyphenyl)ethanone oxime	-	Helicobacter pylori
2-(4-hydroxyphenyl)-1-(2,3,4-trihydroxyphenyl)ethanone oxime	-	Helicobacter pylori
2-(4-hydroxyphenyl)-1-(2,4,6-trihydroxy-3-methoxyphenyl)ethanone oxime	-	Helicobacter pylori
2-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)ethanone oxime	-	Helicobacter pylori
2-(4-methoxyphenyl)-1-(2,3,4-trimethoxyphenyl)ethanamine	-	Helicobacter pylori
4-(1-amino-2-(4-fluorophenyl)ethyl)benzene-1,2,3-triol	-	Helicobacter pylori
4-(1-amino-2-(4-fluorophenyl)ethyl)benzene-1,3-diol	-	Helicobacter pylori
4-(1-amino-2-(4-hydroxyphenyl)ethyl)benzene-1,2,3-triol	-	Helicobacter pylori
4-(1-amino-2-(4-hydroxyphenyl)ethyl)benzene-1,2-diol	-	Helicobacter pylori
4-(1-amino-2-(4-methoxyphenyl)ethyl)benzene-1,3-diol	-	Helicobacter pylori
Acetohydroxamic acid	-	Helicobacter pylori

Organism

Organism	UniProt	Comment	Textmining
Helicobacter pylori	-	ATCC 43504	-

Synonyms

Synonyms	Comment	Organism
Urea amidohydrolase	-	Helicobacter pylori
urease	-	Helicobacter pylori

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.011	-	-	Helicobacter pylori	4-(1-amino-2-(4-hydroxyphenyl)ethyl)benzene-1,2,3-triol
0.017	-	-	Helicobacter pylori	Acetohydroxamic acid
0.047	-	-	Helicobacter pylori	4-(1-amino-2-(4-hydroxyphenyl)ethyl)benzene-1,2-diol

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Release 2023.1 (January 2023)