Literature summary for 3.5.1.5 extracted from

Tanaka, T.; Kawase, M.; Tani, S.
alpha-Hydroxyketones as inhibitors of urease (2004), Bioorg. Med. Chem., 12, 501-505.

Search for more literature for 3.5.1.5

Inhibitors

Inhibitors	Comment	Organism	Structure
2,2'-thenoin	IC50: 0.18 mM	Canavalia ensiformis
2-hydroxy-1-phenylethanone	IC50: 0.47 mM	Canavalia ensiformis
Acetohydroxamic acid	IC50: 0.005 mM	Canavalia ensiformis
acetol	IC50: 2.9 mM	Canavalia ensiformis
furoin	IC50: 0.36 mM	Canavalia ensiformis
Hydroxyurea	IC50: 0.1 mM	Canavalia ensiformis

Organism

Organism	UniProt	Comment	Textmining
Canavalia ensiformis	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
urea + H2O	-	Canavalia ensiformis	CO2 + NH3	-	?

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.005	-	IC50: 0.005 mM	Canavalia ensiformis	Acetohydroxamic acid
0.1	-	IC50: 0.1 mM	Canavalia ensiformis	Hydroxyurea
0.18	-	IC50: 0.18 mM	Canavalia ensiformis	2,2'-thenoin
0.36	-	IC50: 0.36 mM	Canavalia ensiformis	furoin
0.47	-	IC50: 0.47 mM	Canavalia ensiformis	2-hydroxy-1-phenylethanone
2.9	-	IC50: 2.9 mM	Canavalia ensiformis	acetol

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Release 2023.1 (January 2023)