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Literature summary for 3.5.1.36 extracted from
- The effect of aliphatic alcohols and organic solvents on methylpyroglutamate synthetase (1971), J. Biol. Chem., 246, 7804-7809.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| acetone | noncompetitive activator with respect to ethanolamine | Pseudomonas sp. |  |
| aliphatic alcohols | 7fold increase of hydrolysis of alpha-ketoglutaramate and ethyl alpha-ketoglutarate | Pseudomonas sp. | |
| Dimethyl formamide | noncompetitive activator with respect to ethanolamine | Pseudomonas sp. | |
| dioxane | noncompetitive activator, effect on the reaction of methylamine with ethyl alpha-ketoglutarate | Pseudomonas sp. | |
| organic solvents | increase both hydrolysis and transfer reactions involving amines, accelerated up to 7fold | Pseudomonas sp. |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| aliphatic alcohols | with respect to amines in acyl transfer reactions | Pseudomonas sp. | |
| butanol | competitive inhibitors with respect to methylamine and ethanolamine | Pseudomonas sp. | |
| Pentanol | competitive to ethanolamine | Pseudomonas sp. | |
| Propanol | competitive to ethanoamine | Pseudomonas sp. | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Pseudomonas sp. | - |
- |
- |
| Pseudomonas sp. MA / M.A. / ATCC 23819 | - |
- |
- |
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