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Literature summary for 3.5.1.29 extracted from

  • Zhang, J.L.; Zheng, Q.C.; Li, Z.Q.; Zhang, H.X.
    How does (E)-2-(acetamidomethylene)succinate bind to its hydrolase? From the binding process to the final result (2013), PLoS ONE, 8, e53811.
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2-(acetamidomethylene)succinate + 2 H2O Mesorhizobium loti
-
 acetate + succinate semialdehyde + NH3 + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Mesorhizobium loti Q988D4
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-(acetamidomethylene)succinate + 2 H2O
-
 Mesorhizobium loti acetate + succinate semialdehyde + NH3 + CO2
-
 ?
2-(acetamidomethylene)succinate + 2 H2O molecular docking of two substrate isomers E- and Z-2-(acetamidomethylene)succinate to the hydrolase, molecular dynamics simulations and calculations of binding free energies, overview Mesorhizobium loti acetate + succinate semialdehyde + NH3 + CO2
-
 ?

Synonyms

Synonyms Comment Organism
E-2AMS hydrolase
-
 Mesorhizobium loti

General Information

General Information Comment Organism
metabolism binding of (E)-2-(acetamidomethylene)succinate to the enzyme is crucial for biological function of the enzyme and the last step reaction of vitamin B6 biological degradation Mesorhizobium loti
additional information molecular docking of the two substrate isomers E- and Z-2-(acetamidomethylene)succinate to the hydrolase, molecular dynamics simulations and calculations of binding free energies, usage of X-ray crystal structure of E-2AMS hydrolase, PDB ID 3KXP, overview Mesorhizobium loti
physiological function binding of (E)-2-(acetamidomethylene)succinate to the enzyme is crucial for biological function of the enzyme and the last step reaction of vitamin B6 biological degradation Mesorhizobium loti