Literature summary for 3.5.1.26 extracted from

Risley, J.M.; Huang, D.H.; Kaylor, J.J.; Malik, J.J.; Xia, Y.Q.; York, W.M.
Glycosylasparaginase activity requires the alpha-carboxyl group, but not the alpha-amino group, on N(4)-(2-acetamido-2-deoxy-beta-D-glucopyranosyl)-L-asparagine (2001), Arch. Biochem. Biophys., 391, 165-170.

Search for more literature for 3.5.1.26

Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	intramolecular autoproteolytic activation reaction	Homo sapiens

Application

Application	Comment	Organism
medicine	enzyme deficiency or its absence gives rise to aspartylglycosaminuria, the most common disorder of glycoprotein metabolism	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
N4-(2-acetamido-2-deoxy-beta-D-glucopyranosyl)-L-asparagine + H2O	Homo sapiens	catabolism of N-linked oligosaccharides	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
proteolytic modification	intramolecular autoproteolytic activation reaction	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	enzyme catalyzes the hydrolysis of a variety of asparagine and aspartyl compounds containing a free alpha-carboxyl group and a free alpha-amino group, study of enzyme specificity with 14 substrate analogues where the structure of the aspartyl group is changed, the alpha-carboxyl group is necessary for enzyme activity, but not the alpha-amino group, whose position acts as an anchor in the binding site for the substrate, no substrate: N-acetyl-D-glucosamine, intramolecular autoproteolytic activation reaction	Homo sapiens	?	-	?
N4-(2-acetamido-2-deoxy-beta-D-glucopyranosyl)-L-asparagine + H2O	catabolism of N-linked oligosaccharides	Homo sapiens	?	-	?
N4-(2-acetamido-2-deoxy-beta-D-glucopyranosyl)-L-asparagine + H2O	catalyzes the hydrolysis of the N-glycosylic bond	Homo sapiens	2-acetamido-2-deoxy-beta-D-glucopyranosylamine + L-asparagine	-	?

Synonyms

Synonyms	Comment	Organism
glycosylasparaginase	-	Homo sapiens

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Release 2023.1 (January 2023)