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Literature summary for 3.5.1.26 extracted from
- Glycosasparaginase from human leukocytes (1991), J. Biol. Chem., 266, 5860-5869.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 5-Diazo-4-oxo-L-norvaline | irreversible inhibition, Ki: 0.08 mM, competitively protected by its natural substrate | Homo sapiens |  |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.11 | - |
N4-(beta-N-acetyl-D-glucosaminyl)-L-asparagine | - |
Homo sapiens | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 19000 | - |
heavy-chain2, 2 * 25000 + light-chain2, 2 * 19000 | Homo sapiens |
| 25000 | - |
heavy-chain2, 2 * 25000 + light-chain2, 2 * 19000 | Homo sapiens |
| 88000 | - |
non-denaturing PAGE | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| N4-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O | Homo sapiens | - |
2-acetamido-1-amino-1,2-dideoxy-beta-D-glucose + L-aspartate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| to homogeneity, chromatography techniques | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| leukocyte | - |
Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 2.2 | - |
- |
Homo sapiens |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -20°C, 30% glycerol, several months | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| N4-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O | - |
Homo sapiens | 2-acetamido-1-amino-1,2-dideoxy-beta-D-glucose + L-aspartate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| tetramer | heavy-chain2, 2 * 25000 + light-chain2, 2 * 19000 | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| glycoasparaginase | - |
Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7 | 9 | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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