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Literature summary for 3.5.1.24 extracted from

  • Jarocki, P.; Podlesny, M.; Glibowski, P.; Targonski, Z.
    A new insight into the physiological role of bile salt hydrolase among intestinal bacteria from the genus Bifidobacterium (2014), PLoS ONE, 9, e114379.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
phylogenetic tree Bifidobacterium longum
phylogenetic tree Bifidobacterium bifidum
phylogenetic tree Bifidobacterium breve
phylogenetic tree Bifidobacterium pseudocatenulatum
phylogenetic tree Bifidobacterium pseudolongum
phylogenetic tree Bifidobacterium adolescentis
phylogenetic tree Bifidobacterium animalis

Inhibitors

Inhibitors Comment Organism Structure
4-chloromercuriacetate over 98% inhibition at 0.01 mM Bifidobacterium longum
4-chloromercuriacetate over 98% inhibition at 0.01 mM Bifidobacterium pseudocatenulatum
Cu2+ complete inhibition at 5 mM Bifidobacterium longum
Cu2+ complete inhibition at 5 mM Bifidobacterium pseudocatenulatum
Hg2+ 98% inhibition at 0.2 mM Bifidobacterium longum
Hg2+ 96% inhibition at 0.2 mM Bifidobacterium pseudocatenulatum
iodoacetamide 44% inhibition at 30 mM Bifidobacterium longum
iodoacetamide 64.5% inhibition at 30 mM Bifidobacterium pseudocatenulatum
N-ethylmaleimide 69% inhibition at 5 mM Bifidobacterium longum
N-ethylmaleimide 52% inhibition at 5 mM Bifidobacterium pseudocatenulatum
periodic acid complete inhibition at 3 mM Bifidobacterium longum
periodic acid complete inhibition at 3 mM Bifidobacterium pseudocatenulatum

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ activates 20% at 30 mM Bifidobacterium pseudocatenulatum
Ca2+ activates 20% at 30 mM Bifidobacterium longum
additional information poor activating effect at 30 mM Bifidobacterium pseudocatenulatum
additional information poor activating effect at 30 mM Bifidobacterium longum
Na+ activates 10% at 50 mM Bifidobacterium pseudocatenulatum
Na+ activates 10% at 50 mM Bifidobacterium longum

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
35000
-
x * 35000, DS-PAGE Bifidobacterium pseudocatenulatum
35000
-
x * 35000, DS-PAGE Bifidobacterium longum
107000 124000 native enzyme, gel filtration Bifidobacterium longum
123000 154000 native enzyme, gel filtration Bifidobacterium pseudocatenulatum

Organism

Organism UniProt Comment Textmining
Bifidobacterium adolescentis I3QNS7 isolated from bovine rumen
-
Bifidobacterium adolescentis DSM 20087 I3QNS7 isolated from bovine rumen
-
Bifidobacterium animalis I3QNS8 subps. animalis , isolated from rat feces
-
Bifidobacterium animalis I3QNS9 subsp. lactis, isolated from yoghurt
-
Bifidobacterium animalis NRRL B-41405 I3QNS9 subsp. lactis, isolated from yoghurt
-
Bifidobacterium animalis NRRL B-41406 I3QNS8 subps. animalis , isolated from rat feces
-
Bifidobacterium bifidum I3QNT0 isolated from stool of breast-fed infant
-
Bifidobacterium bifidum DSM 20456 I3QNT0 isolated from stool of breast-fed infant
-
Bifidobacterium breve I3QNT2 isolated from intestine of infant
-
Bifidobacterium breve DSM 20091 I3QNT2 isolated from intestine of infant
-
Bifidobacterium breve NRRL B-41408 I3QNT2 isolated from intestine of infant
-
Bifidobacterium longum
-
subsp. longum, isolated from intestine of adult
-
Bifidobacterium longum A0A087D2Y1 subsp. suis, isolated from pig feces
-
Bifidobacterium longum I3QNT4 subsp. infantis, isolated from intestine of infant
-
Bifidobacterium longum ATCC 15697 I3QNT4 subsp. infantis, isolated from intestine of infant
-
Bifidobacterium longum NRRL B-41407 A0A087D2Y1 subsp. suis, isolated from pig feces
-
Bifidobacterium longum NRRL B-41409
-
subsp. longum, isolated from intestine of adult
-
Bifidobacterium pseudocatenulatum I3QNT6 isolated from sewage
-
Bifidobacterium pseudocatenulatum DSM 20224 I3QNT6 isolated from sewage
-
Bifidobacterium pseudocatenulatum DSM 20439 I3QNT6 isolated from sewage
-
Bifidobacterium pseudolongum L0CM48 subsp. pseudolongum, isolated from bovine rumen
-
Bifidobacterium pseudolongum DSM 20095 L0CM48 subsp. pseudolongum, isolated from bovine rumen
-
no activity in Bifidobacterium asteroides DSM 20089
-
-
-
no activity in Bifidobacterium coryneforme DSM 20216
-
-
-
no activity in Lactobacillus rhamnosus strain NRRL B-442
-
-
-

Purification (Commentary)

Purification (Comment) Organism
native enzyme by gel filtration, hydrophobic interaction chromatography, and ion exchange chromatography Bifidobacterium pseudocatenulatum
native enzyme by gel filtration, hydrophobic interaction chromatography, and ion exchange chromatography Bifidobacterium longum

Source Tissue

Source Tissue Comment Organism Textmining

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
high activity in Bifidobacterium longum strain NRRL B-41407 Bifidobacterium longum
additional information
-
low activity in Bifidobacterium bifidum strain DSM 20456 Bifidobacterium bifidum
additional information
-
low activity in Bifidobacterium breve strain DSM 20091 Bifidobacterium breve
additional information
-
low activity in Bifidobacterium breve strain NRRL B-41408 Bifidobacterium breve
additional information
-
low activity in Bifidobacterium longum strain ATCC 15697 Bifidobacterium longum
additional information
-
low activity in Bifidobacterium longum subsp. longum strain NRRL B-41409 Bifidobacterium longum
additional information
-
lower activity in Bifidobacterium pseudocatenulatum strain DSM 20224 Bifidobacterium pseudocatenulatum
additional information
-
moderate activity in Bifidobacterium pseudocatenulatum strain DSM 20439 Bifidobacterium pseudocatenulatum
additional information
-
very high activity in Bifidobacterium animalis strain NRRL B-41405 Bifidobacterium animalis
additional information
-
very low activity in Bifidobacterium adolescentis strain DSM 20087 Bifidobacterium adolescentis
additional information
-
very low activity in Bifidobacterium animalis strain NRRL B-41406 Bifidobacterium animalis
additional information
-
very low activity in Bifidobacterium pseudolongum strain DSM 20095 Bifidobacterium pseudolongum

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glycochenodeoxycholic acid + H2O best substrate Bifidobacterium pseudocatenulatum chenodeoxycholate + glycine
-
?
glycochenodeoxycholic acid + H2O best substrate Bifidobacterium longum chenodeoxycholate + glycine
-
?
glycochenodeoxycholic acid + H2O best substrate Bifidobacterium pseudocatenulatum DSM 20224 chenodeoxycholate + glycine
-
?
glycochenodeoxycholic acid + H2O best substrate Bifidobacterium pseudocatenulatum DSM 20439 chenodeoxycholate + glycine
-
?
glycochenodeoxycholic acid + H2O best substrate Bifidobacterium longum NRRL B-41407 chenodeoxycholate + glycine
-
?
glycocholic acid + H2O
-
Bifidobacterium pseudocatenulatum cholate + glycine
-
?
glycocholic acid + H2O
-
Bifidobacterium longum cholate + glycine
-
?
glycodeoxycholic acid + H2O
-
Bifidobacterium longum deoxycholate + glycine
-
?
glycodeoxycholic acid + H2O
-
Bifidobacterium bifidum deoxycholate + glycine
-
?
glycodeoxycholic acid + H2O
-
Bifidobacterium breve deoxycholate + glycine
-
?
glycodeoxycholic acid + H2O
-
Bifidobacterium pseudocatenulatum deoxycholate + glycine
-
?
glycodeoxycholic acid + H2O
-
Bifidobacterium pseudolongum deoxycholate + glycine
-
?
glycodeoxycholic acid + H2O
-
Bifidobacterium adolescentis deoxycholate + glycine
-
?
glycodeoxycholic acid + H2O
-
Bifidobacterium animalis deoxycholate + glycine
-
?
glycodeoxycholic acid + H2O
-
Bifidobacterium pseudocatenulatum DSM 20224 deoxycholate + glycine
-
?
glycodeoxycholic acid + H2O
-
Bifidobacterium bifidum DSM 20456 deoxycholate + glycine
-
?
glycodeoxycholic acid + H2O
-
Bifidobacterium animalis NRRL B-41406 deoxycholate + glycine
-
?
glycodeoxycholic acid + H2O
-
Bifidobacterium animalis NRRL B-41405 deoxycholate + glycine
-
?
glycodeoxycholic acid + H2O
-
Bifidobacterium pseudocatenulatum DSM 20439 deoxycholate + glycine
-
?
glycodeoxycholic acid + H2O
-
Bifidobacterium longum NRRL B-41409 deoxycholate + glycine
-
?
glycodeoxycholic acid + H2O
-
Bifidobacterium longum NRRL B-41407 deoxycholate + glycine
-
?
glycodeoxycholic acid + H2O
-
Bifidobacterium longum ATCC 15697 deoxycholate + glycine
-
?
glycodeoxycholic acid + H2O
-
Bifidobacterium breve DSM 20091 deoxycholate + glycine
-
?
glycodeoxycholic acid + H2O
-
Bifidobacterium breve NRRL B-41408 deoxycholate + glycine
-
?
glycodeoxycholic acid + H2O
-
Bifidobacterium pseudolongum DSM 20095 deoxycholate + glycine
-
?
glycodeoxycholic acid + H2O
-
Bifidobacterium adolescentis DSM 20087 deoxycholate + glycine
-
?
additional information substrate specificity of the purified enzyme, overview Bifidobacterium pseudocatenulatum ?
-
?
additional information substrate specificity of the purified enzyme, overview Bifidobacterium longum ?
-
?
additional information substrate specificity of the purified enzyme, overview Bifidobacterium pseudocatenulatum DSM 20224 ?
-
?
additional information substrate specificity of the purified enzyme, overview Bifidobacterium pseudocatenulatum DSM 20439 ?
-
?
additional information substrate specificity of the purified enzyme, overview Bifidobacterium longum NRRL B-41407 ?
-
?
taurochenodeoxycholic acid + H2O
-
Bifidobacterium pseudocatenulatum chenodeoxycholate + taurine
-
?
taurochenodeoxycholic acid + H2O
-
Bifidobacterium longum chenodeoxycholate + taurine
-
?
taurochenodeoxycholic acid + H2O
-
Bifidobacterium pseudocatenulatum DSM 20224 chenodeoxycholate + taurine
-
?
taurochenodeoxycholic acid + H2O
-
Bifidobacterium pseudocatenulatum DSM 20439 chenodeoxycholate + taurine
-
?
taurochenodeoxycholic acid + H2O
-
Bifidobacterium longum NRRL B-41407 chenodeoxycholate + taurine
-
?
taurocholic acid + H2O
-
Bifidobacterium pseudocatenulatum cholate + taurine
-
?
taurocholic acid + H2O
-
Bifidobacterium longum cholate + taurine
-
?
taurodeoxycholic acid + H2O
-
Bifidobacterium longum deoxycholate + taurine
-
?
taurodeoxycholic acid + H2O
-
Bifidobacterium bifidum deoxycholate + taurine
-
?
taurodeoxycholic acid + H2O
-
Bifidobacterium breve deoxycholate + taurine
-
?
taurodeoxycholic acid + H2O
-
Bifidobacterium pseudocatenulatum deoxycholate + taurine
-
?
taurodeoxycholic acid + H2O
-
Bifidobacterium pseudolongum deoxycholate + taurine
-
?
taurodeoxycholic acid + H2O
-
Bifidobacterium adolescentis deoxycholate + taurine
-
?
taurodeoxycholic acid + H2O
-
Bifidobacterium animalis deoxycholate + taurine
-
?
taurodeoxycholic acid + H2O
-
Bifidobacterium pseudocatenulatum DSM 20224 deoxycholate + taurine
-
?
taurodeoxycholic acid + H2O
-
Bifidobacterium bifidum DSM 20456 deoxycholate + taurine
-
?
taurodeoxycholic acid + H2O
-
Bifidobacterium animalis NRRL B-41406 deoxycholate + taurine
-
?
taurodeoxycholic acid + H2O
-
Bifidobacterium animalis NRRL B-41405 deoxycholate + taurine
-
?
taurodeoxycholic acid + H2O
-
Bifidobacterium pseudocatenulatum DSM 20439 deoxycholate + taurine
-
?
taurodeoxycholic acid + H2O
-
Bifidobacterium longum NRRL B-41409 deoxycholate + taurine
-
?
taurodeoxycholic acid + H2O
-
Bifidobacterium longum NRRL B-41407 deoxycholate + taurine
-
?
taurodeoxycholic acid + H2O
-
Bifidobacterium longum ATCC 15697 deoxycholate + taurine
-
?
taurodeoxycholic acid + H2O
-
Bifidobacterium breve DSM 20091 deoxycholate + taurine
-
?
taurodeoxycholic acid + H2O
-
Bifidobacterium breve NRRL B-41408 deoxycholate + taurine
-
?
taurodeoxycholic acid + H2O
-
Bifidobacterium pseudolongum DSM 20095 deoxycholate + taurine
-
?
taurodeoxycholic acid + H2O
-
Bifidobacterium adolescentis DSM 20087 deoxycholate + taurine
-
?

Subunits

Subunits Comment Organism
oligomer x * 35000, DS-PAGE Bifidobacterium pseudocatenulatum
oligomer x * 35000, DS-PAGE Bifidobacterium longum

Synonyms

Synonyms Comment Organism
bile salt hydrolase
-
Bifidobacterium longum
bile salt hydrolase
-
Bifidobacterium bifidum
bile salt hydrolase
-
Bifidobacterium breve
bile salt hydrolase
-
Bifidobacterium pseudocatenulatum
bile salt hydrolase
-
Bifidobacterium pseudolongum
bile salt hydrolase
-
Bifidobacterium adolescentis
bile salt hydrolase
-
Bifidobacterium animalis

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
-
Bifidobacterium pseudocatenulatum
37
-
assay at Bifidobacterium longum
37
-
assay at Bifidobacterium bifidum
37
-
assay at Bifidobacterium breve
37
-
assay at Bifidobacterium pseudolongum
37
-
assay at Bifidobacterium adolescentis
37
-
assay at Bifidobacterium animalis

Temperature Range [°C]

Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
25 60 activity above 50% of maximal activity within this range, profile overview Bifidobacterium pseudocatenulatum
25 55 activity above 50% of maximal activity within this range, profile overview Bifidobacterium longum

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
60 70 purified enzyme, significant decrease of catalytic activity at temperatures higher than 60°C, with 11% of maximum activity at 70°C Bifidobacterium longum
60 70 purified enzyme, significant decrease of catalytic activity at temperatures higher than 60°C, with 18% of maximum activity at 70°C Bifidobacterium pseudocatenulatum

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5
-
-
Bifidobacterium pseudocatenulatum
5
-
-
Bifidobacterium longum
6
-
assay at Bifidobacterium longum
6
-
assay at Bifidobacterium bifidum
6
-
assay at Bifidobacterium breve
6
-
assay at Bifidobacterium pseudolongum
6
-
assay at Bifidobacterium adolescentis
6
-
assay at Bifidobacterium animalis

pH Range

pH Minimum pH Maximum Comment Organism
4.5 6.5 activity above 30% of maximal activity within this range, profile overview Bifidobacterium pseudocatenulatum
4.5 6.5 activity above 40% of maximal activity within this range, profile overview Bifidobacterium longum

General Information

General Information Comment Organism
evolution phylogenetic tree Bifidobacterium longum
evolution phylogenetic tree Bifidobacterium bifidum
evolution phylogenetic tree Bifidobacterium breve
evolution phylogenetic tree Bifidobacterium pseudocatenulatum
evolution phylogenetic tree Bifidobacterium pseudolongum
evolution phylogenetic tree Bifidobacterium adolescentis
evolution phylogenetic tree Bifidobacterium animalis