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Literature summary for 3.5.1.24 extracted from

  • Sridevi, N.; Prabhune, A.A.
    Brevibacillus sp: A novel thermophilic source for the production of bile salt hydrolase (2009), Appl. Biochem. Biotechnol., 157, 254-262.
    View publication on PubMed
Search for more literature for 3.5.1.24

Application

Application Comment Organism
medicine using bile salt deconjugation to lower serum cholesterol levels in hypercholesteremic patients and prevent hypercholesteremia in normal people is of great interest Brevibacillus sp.

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Brevibacillus sp. catalyzes the hydrolysis of glycine- and taurine-conjugated bile salts to amino acid residues and free bile salts ?
-
 ?

Organism

Organism UniProt Comment Textmining
Brevibacillus sp.
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 glycocholic acid 2.2 U, glycodeoxycholic acid 2.7 U, glycochenodeoxycholic acid 1.7 U, taurocholic acid 1.7 U, taurodeoxycholic acid 1.7 U, taurochenodeoxycholic acid 1.7 U Brevibacillus sp.

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glycochenodeoxycholic acid + H2O
-
 Brevibacillus sp. 3alpha,7alpha-dihydroxy-5beta-cholanate + Gly
-
 ?
glycocholic acid + H2O
-
 Brevibacillus sp. 3alpha,7alpha,12alpha-trihydroxy-5beta-cholanate + Gly
-
 ?
glycodeoxycholic acid + H2O
-
 Brevibacillus sp. 3alpha,12alpha-dihydroxy-5beta-cholanate + Gly
-
 ?
additional information catalyzes the hydrolysis of glycine- and taurine-conjugated bile salts to amino acid residues and free bile salts Brevibacillus sp. ?
-
 ?
taurochenodeoxycholic acid + H2O
-
 Brevibacillus sp. chenodeoxycholate + taurine
-
 ?
taurocholic acid + H2O
-
 Brevibacillus sp. 3alpha,7alpha,12alpha-trihydroxy-5beta-cholanate + taurine
-
 ?
taurodeoxycholic acid + H2O
-
 Brevibacillus sp. 3alpha,12alpha-dihydroxy-5beta-cholanate + taurine
-
 ?

Synonyms

Synonyms Comment Organism
bile salt hydrolase
-
 Brevibacillus sp.

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
40
-
 bile salt hydrolase assay Brevibacillus sp.

Temperature Range [°C]

Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
40 65
-
 Brevibacillus sp.

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.5
-
 bile salt hydrolase assay Brevibacillus sp.

pH Range

pH Minimum pH Maximum Comment Organism
6 9
-
 Brevibacillus sp.