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Literature summary for 3.5.1.23 extracted from
- Downregulation of neutral ceramidase by gemcitabine: Implications for cell cycle regulation (2009), Biochim. Biophys. Acta, 1791, 730-739.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| gemcitabine | - |
Mus musculus |  |
| NCDase siRNA | - |
Mus musculus |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 95000 | - |
determined by SDS-PAGE and Western blot analysis, the multiple band pattern between about 95 and 135 kDa may be due to the complexity of modifications, such as O-glycosylation and N-glycosylation | Mus musculus |
| 135000 | - |
determined by SDS-PAGE and Western blot analysis, the multiple band pattern between about 95 and 135 kDa may be due to the complexity of modifications, such as O-glycosylation and N-glycosylation | Mus musculus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Mus musculus | ceramidase catalyzes the hydrolysis of ceramide to form sphingosine and free fatty acid | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| glycoprotein | - |
Mus musculus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| endothelial cell line | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-erythro-C12-NBD-ceramide + H2O | substrate in activity assay | Mus musculus | D-erythro-sphingosine + 4-nitrobenzo-2-oxa-1,3-diazoyl-dodecanoic acid | - |
? | |
| additional information | ceramidase catalyzes the hydrolysis of ceramide to form sphingosine and free fatty acid | Mus musculus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ceramidase | - |
Mus musculus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 5 | - |
activity assay, for acid ceramidase activity | Mus musculus |
| 7 | - |
activity assay, for neutral ceramidase activity | Mus musculus |
| 9 | - |
activity assay, for alkaline ceramidase activity | Mus musculus |
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Release 2023.1 (January 2023)
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