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Literature summary for 3.5.1.23 extracted from

  • Zhu, Q.; Jin, J.F.; Shan, X.H.; Liu, C.P.; Mao, X.D.; Xu, K.F.; Liu, C.
    Chronic activation of neutral ceramidase protects beta-cells against cytokine-induced apoptosis (2008), Acta Pharmacol. Sin., 29, 593-599.
    View publication on PubMed
Search for more literature for 3.5.1.23

Activating Compound

Activating Compound Comment Organism Structure
cytokine a cytokine mixture of interleukin-1beta, tumor necrose factor-alpha and interferon-gamma is used Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
siRNA
-
 Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
110000
-
 determined by SDS-PAGE and Western Blot analysis Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus ceramidase deacylates ceramide to form sphingosine ?
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus Q91XT9
-
-

Source Tissue

Source Tissue Comment Organism Textmining
INS-1 cell
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information ceramidase deacylates ceramide to form sphingosine Rattus norvegicus ?
-
 ?

Synonyms

Synonyms Comment Organism
ceramidase
-
 Rattus norvegicus
N-CDase
-
 Rattus norvegicus
neutral ceramidase
-
 Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 N-CDase activity assay Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 N-CDase activity assay Rattus norvegicus