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Literature summary for 3.5.1.22 extracted from
- Kinetic studies on pantothenase of Pseudomonas fluorescens (1976), Biochem. J., 157, 415-421.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| oxalate | - |
Pseudomonas fluorescens |  |
| oxaloacetate | noncompetitive inhibition, dependent on pH | Pseudomonas fluorescens | |
| Phenylmethanesulfonylfluoride | - |
Pseudomonas fluorescens | |
| pyruvate | - |
Pseudomonas fluorescens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 5 | - |
pantothenic acid | P-2, pH 7.5 at 28°C | Pseudomonas fluorescens | |
| 7.6 | - |
pantothenic acid | pH-independent theoretical Km | Pseudomonas fluorescens | |
| 12.5 | - |
pantothenic acid | 60 mM potassium phosphate, pH 7.4 | Pseudomonas fluorescens | |
| 13 | - |
pantothenic acid | 20 mM potassium phosphate, pH 7.4 | Pseudomonas fluorescens | |
| 15 | - |
pantothenic acid | 5 mM potassium phosphate, pH 7.4 | Pseudomonas fluorescens | |
| 18 | - |
pantothenic acid | 10 mM sodium diphosphate/H2SO4, pH 7.5 | Pseudomonas fluorescens | |
| 22 | - |
pantothenic acid | 10 mM Tris/H2SO4, pH 7.5 | Pseudomonas fluorescens | |
| 24 | - |
pantothenic acid | 10 mM Tris/10 mM citric acid(KOH), pH 7.5 | Pseudomonas fluorescens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| pantothenic acid + H2O | Pseudomonas fluorescens | - |
? | - |
? | |
| pantothenic acid + H2O | Pseudomonas fluorescens P-2 | - |
? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Pseudomonas fluorescens | - |
P-2 | - |
| Pseudomonas fluorescens | - |
NCIB12017, earlier Pseudomonas fluorescens UK-1, isolated from sea water | - |
| Pseudomonas fluorescens P-2 | - |
P-2 | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Pseudomonas fluorescens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| pantothenic acid + H2O | - |
Pseudomonas fluorescens | beta-alanine + D-pantoyl lactone + H2O | - |
r | |
| pantothenic acid + H2O | - |
Pseudomonas fluorescens P-2 | beta-alanine + D-pantoyl lactone + H2O | - |
r | |
| pantothenic acid + H2O | - |
Pseudomonas fluorescens | ? | - |
? | |
| pantothenic acid + H2O | - |
Pseudomonas fluorescens P-2 | ? | - |
? | |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 5.5 | 9 | - |
Pseudomonas fluorescens |
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