Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Homo sapiens | 5739 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
additional information | GLS2 expression is lost or greatly decreased in hepatocellular carcinomas and the overexpression of GLS2 greatly reduces tumor cell colony formation | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-glutamine + H2O | - |
Homo sapiens | L-glutamate + NH3 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
GLS2 | - |
Homo sapiens |
glutaminase 2 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | GLS2 expression is lost or greatly decreased in hepatocellular carcinomas and the overexpression of GLS2 greatly reduces tumor cell colony formation | additional information |
Homo sapiens | p53 increases the GLS2 expression under both nonstressed and stressed conditions | up |
General Information | Comment | Organism |
---|---|---|
physiological function | GLS2 identified as a previously uncharacterized p53 target gene to regulate cellular energy metabolism and antioxidant defense. GLS regulates cellular energy metabolism by increasing production of glutamate and 2-oxoglutarate, which in turn results in enhanced mitochondrial respiration and ATP generation. Furthemore GLS2 regulates antioxidant defense function in cells by increasing reduced glutathione levels and decreasing reactive oxygen spcies (ROS) levels, which in turn protects cells from oxidative stress | Homo sapiens |