Literature summary for 3.5.1.2 extracted from

Robinson, M.M.; McBryant, S.J.; Tsukamoto, T.; Rojas, C.; Ferraris, D.V.; Hamilton, S.K.; Hansen, J.C.; Curthoys, N.P.
Novel mechanism of inhibition of rat kidney-type glutaminase by bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide (BPTES) (2007), Biochem. J., 406, 407-414.

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Inhibitors

Inhibitors	Comment	Organism	Structure
bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide	a potent inhibitor of kidney-type glutaminase, but not of the liver-type glutaminase, glutamate dehydrogenase or gamma-glutamyl transpeptidase. The potent inhibitor causes the formation of a stable, but inactive, tetramer	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	Sprague-Dawley	-
Rattus norvegicus Sprague-Dawley	-	Sprague-Dawley	-

Synonyms

Synonyms	Comment	Organism
kidney-type glutaminase	-	Rattus norvegicus

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.003	-	bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide	-	Rattus norvegicus

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Release 2023.1 (January 2023)