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Literature summary for 3.5.1.2 extracted from

  • Romero-Gomez, M.
    Role of phosphate-activated glutaminase in the pathogenesis of hepatic encephalopathy (2005), Metab. Brain Dis., 20, 319-325.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
angiotensin II activates Homo sapiens
glucagon activates Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
6-diazo-5-oxo-L-norleucine blockade of PAG, avoids the toxic effects of Gln accumulation in the brain Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
phosphate phosphate-activated glutaminase isozyme Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-glutamine + H2O Homo sapiens glutamine synthesis pathway, overview, the intestinal and brain phosphate-activated glutaminase plays a role in the pathogenesis of hepatic encephalopathy, overview, PAG is increased in cirrhotics showing minimal hepatic encephalopathy and, therefore, could be implicated in the production of systemic hyperammonemia in these patients, PAG localized into the astrocytes is responsible for ammonia and free-radical production, PAG regulation mechanism, overview L-glutamate + NH3
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
phosphate-activated isozyme, kidney type isozyme K-PAG and the hepatic type isozyme L-PAG
-

Source Tissue

Source Tissue Comment Organism Textmining
astrocyte phosphate-activated isozyme Homo sapiens
-
brain phosphate-activated isozyme, isozyme K-PAG Homo sapiens
-
duodenum phosphate-activated isozyme, mucosa Homo sapiens
-
gastrointestinal tract phosphate-activated isozyme Homo sapiens
-
gut phosphate-activated isozyme Homo sapiens
-
kidney isozyme K-PAG Homo sapiens
-
liver phosphate-activated isozyme, isozyme L-PAG Homo sapiens
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additional information isozyme tissue distribution, overview, isozyme K-PAG is located in kidney, brain, and villus enterocyte, while isozyme L-PAG is restricted to the liver Homo sapiens
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mucosa duodenal Homo sapiens
-
small intestine phosphate-activated isozyme Homo sapiens
-
villus isozyme K-PAG Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-glutamine + H2O
-
Homo sapiens L-glutamate + NH3
-
?
L-glutamine + H2O glutamine synthesis pathway, overview, the intestinal and brain phosphate-activated glutaminase plays a role in the pathogenesis of hepatic encephalopathy, overview, PAG is increased in cirrhotics showing minimal hepatic encephalopathy and, therefore, could be implicated in the production of systemic hyperammonemia in these patients, PAG localized into the astrocytes is responsible for ammonia and free-radical production, PAG regulation mechanism, overview Homo sapiens L-glutamate + NH3
-
?

Synonyms

Synonyms Comment Organism
PAG
-
Homo sapiens
phosphate-activated glutaminase
-
Homo sapiens