Activating Compound | Comment | Organism | Structure |
---|---|---|---|
angiotensin II | activates | Homo sapiens | |
glucagon | activates | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
6-diazo-5-oxo-L-norleucine | blockade of PAG, avoids the toxic effects of Gln accumulation in the brain | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
phosphate | phosphate-activated glutaminase isozyme | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-glutamine + H2O | Homo sapiens | glutamine synthesis pathway, overview, the intestinal and brain phosphate-activated glutaminase plays a role in the pathogenesis of hepatic encephalopathy, overview, PAG is increased in cirrhotics showing minimal hepatic encephalopathy and, therefore, could be implicated in the production of systemic hyperammonemia in these patients, PAG localized into the astrocytes is responsible for ammonia and free-radical production, PAG regulation mechanism, overview | L-glutamate + NH3 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
phosphate-activated isozyme, kidney type isozyme K-PAG and the hepatic type isozyme L-PAG | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
astrocyte | phosphate-activated isozyme | Homo sapiens | - |
brain | phosphate-activated isozyme, isozyme K-PAG | Homo sapiens | - |
duodenum | phosphate-activated isozyme, mucosa | Homo sapiens | - |
gastrointestinal tract | phosphate-activated isozyme | Homo sapiens | - |
gut | phosphate-activated isozyme | Homo sapiens | - |
kidney | isozyme K-PAG | Homo sapiens | - |
liver | phosphate-activated isozyme, isozyme L-PAG | Homo sapiens | - |
additional information | isozyme tissue distribution, overview, isozyme K-PAG is located in kidney, brain, and villus enterocyte, while isozyme L-PAG is restricted to the liver | Homo sapiens | - |
mucosa | duodenal | Homo sapiens | - |
small intestine | phosphate-activated isozyme | Homo sapiens | - |
villus | isozyme K-PAG | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-glutamine + H2O | - |
Homo sapiens | L-glutamate + NH3 | - |
? | |
L-glutamine + H2O | glutamine synthesis pathway, overview, the intestinal and brain phosphate-activated glutaminase plays a role in the pathogenesis of hepatic encephalopathy, overview, PAG is increased in cirrhotics showing minimal hepatic encephalopathy and, therefore, could be implicated in the production of systemic hyperammonemia in these patients, PAG localized into the astrocytes is responsible for ammonia and free-radical production, PAG regulation mechanism, overview | Homo sapiens | L-glutamate + NH3 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PAG | - |
Homo sapiens |
phosphate-activated glutaminase | - |
Homo sapiens |