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Literature summary for 3.5.1.2 extracted from

  • Baglietto-Vargas, D.; Lopez-Tellez, J.F.; Moreno-Gonzalez, I.; Gutierrez, A.; Aledo, J.C.
    Segregation of two glutaminase isoforms in islets of Langerhans (2004), Biochem. J., 381, 483-487.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-glutamine + H2O Rattus norvegicus
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L-glutamate + NH3
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?
additional information Rattus norvegicus the spatial segregation of tissue-specific isozymes in pancreas alpha- and beta-cells may have important functional implications, facilitating a differential regulation of glutamate production in insulin- and glucagon-secreting cells, overview ?
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?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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male sprague-dawley rats
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Purification (Commentary)

Purification (Comment) Organism
partially from rat pancreas by preparation of islets of Langerhans Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
brain expression of both isozymes, the isozyme KGA/LGA ratio is very high in brain Rattus norvegicus
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kidney kidney-type isozyme, KGA Rattus norvegicus
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Langerhans cell
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Rattus norvegicus
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liver expression of both isozymes, but mainly of the liver-type isozyme, LGA, the isozyme KGA/LGA ratio is very low in liver Rattus norvegicus
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pancreas expression of both isozymes, the kidney-type, KGA, and the liver-type, LGA, with a complementary cellular pattern of expression, KGA is mainly present in alpha-cells, LGA is very abundant in beta-cells Rattus norvegicus
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pancreatic islet
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Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-glutamine + H2O
-
Rattus norvegicus L-glutamate + NH3
-
?
additional information the spatial segregation of tissue-specific isozymes in pancreas alpha- and beta-cells may have important functional implications, facilitating a differential regulation of glutamate production in insulin- and glucagon-secreting cells, overview Rattus norvegicus ?
-
?

Synonyms

Synonyms Comment Organism
GA
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Rattus norvegicus
KGA
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Rattus norvegicus
kidney-type glutaminase
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Rattus norvegicus
LGA
-
Rattus norvegicus
liver-type glutaminase
-
Rattus norvegicus