Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-glutamine + H2O | Rattus norvegicus | - |
L-glutamate + NH3 | - |
? | |
additional information | Rattus norvegicus | the spatial segregation of tissue-specific isozymes in pancreas alpha- and beta-cells may have important functional implications, facilitating a differential regulation of glutamate production in insulin- and glucagon-secreting cells, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
male sprague-dawley rats | - |
Purification (Comment) | Organism |
---|---|
partially from rat pancreas by preparation of islets of Langerhans | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | expression of both isozymes, the isozyme KGA/LGA ratio is very high in brain | Rattus norvegicus | - |
kidney | kidney-type isozyme, KGA | Rattus norvegicus | - |
Langerhans cell | - |
Rattus norvegicus | - |
liver | expression of both isozymes, but mainly of the liver-type isozyme, LGA, the isozyme KGA/LGA ratio is very low in liver | Rattus norvegicus | - |
pancreas | expression of both isozymes, the kidney-type, KGA, and the liver-type, LGA, with a complementary cellular pattern of expression, KGA is mainly present in alpha-cells, LGA is very abundant in beta-cells | Rattus norvegicus | - |
pancreatic islet | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-glutamine + H2O | - |
Rattus norvegicus | L-glutamate + NH3 | - |
? | |
additional information | the spatial segregation of tissue-specific isozymes in pancreas alpha- and beta-cells may have important functional implications, facilitating a differential regulation of glutamate production in insulin- and glucagon-secreting cells, overview | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
GA | - |
Rattus norvegicus |
KGA | - |
Rattus norvegicus |
kidney-type glutaminase | - |
Rattus norvegicus |
LGA | - |
Rattus norvegicus |
liver-type glutaminase | - |
Rattus norvegicus |