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Literature summary for 3.5.1.2 extracted from

  • Nelson, D.; Rumsey, W.L.; Erecinska, M.
    Glutamine catabolism by heart muscle. Properties of phosphate-activated glutaminase (1992), Biochem. J., 282, 559-564.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.5.1.2

Activating Compound

Activating Compound Comment Organism Structure
ATP enhances activity Rattus norvegicus
citrate enhances activity Rattus norvegicus
Lactate enhances activity Rattus norvegicus
malate enhances activity Rattus norvegicus
phosphate activates Rattus norvegicus
sulfate activates Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
glutamate
-
 Rattus norvegicus
NEM 1 mM, almost completely blocks activity Rattus norvegicus
NH4+ no effect Rattus norvegicus
Triton X-100
-
 Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.4
-
 Gln
-
 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Rattus norvegicus 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-Gln + H2O Rattus norvegicus the enzyme produces myocardial Glu L-Glu + NH3
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Gln + H2O
-
 Rattus norvegicus Glu + NH3
-
 ?
L-Gln + H2O the enzyme produces myocardial Glu Rattus norvegicus L-Glu + NH3
-
 ?