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Literature summary for 3.5.1.18 extracted from

  • Starus, A.; Nocek, B.; Bennett, B.; Larrabee, J.A.; Shaw, D.L.; Sae-Lee, W.; Russo, M.T.; Gillner, D.M.; Makowska-Grzyska, M.; Joachimiak, A.; Holz, R.C.
    Inhibition of the dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase from Neisseria meningitidis by L-captopril (2015), Biochemistry, 54, 4834-4844 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.5.1.18

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli BL21(DE3) Neisseria meningitidis

Crystallization (Commentary)

Crystallization (Comment) Organism
sitting-drop vapor-diffusion method at 16°C, three-dimensional X-ray crystal structure of the enzyme in complex with L-captopril at 1.8 A resolution Neisseria meningitidis

Inhibitors

Inhibitors Comment Organism Structure
L-captopril competitive inhibitor Neisseria meningitidis

Metals/Ions

Metals/Ions Comment Organism Structure
Co2+ EPR and MCD data indicate that the two Co(II) ions in DapE are antiferromagnetically coupled Neisseria meningitidis

Organism

Organism UniProt Comment Textmining
Neisseria meningitidis Q9JYL2
-
-
Neisseria meningitidis MC58 Q9JYL2
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-succinyl-LL-2,6-diaminoheptanedioate + H2O
-
 Neisseria meningitidis succinate + LL-2,6-diaminoheptanedioate
-
 ?
N-succinyl-LL-2,6-diaminoheptanedioate + H2O
-
 Neisseria meningitidis MC58 succinate + LL-2,6-diaminoheptanedioate
-
 ?

Synonyms

Synonyms Comment Organism
DapE
-
 Neisseria meningitidis

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0028
-
 L-captopril 25°C, pH 7.5 Neisseria meningitidis