Literature summary for 3.5.1.18 extracted from

Hlavacek, J.; Vitovcova, M.; Sazelova, P.; Picha, J.; Vanek, V.; Budesinsky, M.; Jiracek, J.; Gillner, D.M.; Holz, R.C.; Miksik, I.; Kasicka, V.
Mono-N-acyl-2,6-diaminopimelic acid derivatives: analysis by electromigration and spectroscopic methods and examination of enzyme inhibitory activity (2014), Anal. Biochem., 467, 4-13.

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Inhibitors

Inhibitors	Comment	Organism	Structure
2-amino-6-[(2-methylpropanoyl)amino]heptanedioic acid	slight inhibition	Haemophilus influenzae
additional information	mono-N-acyl derivatives of 2,6-diaminopimelic acid are no effective N-succinyl-L,L-diaminopimelic acid desuccinylase inhibitors, overview. No inhibition by 2-amino-6-(butanoylamino)heptanedioic acid, 2-amino-6-[(2,2-dimethylpropanoyl)amino]heptanedioic acid, 2-amino-6-(pentanoylamino)heptanedioic acid, 2-amino-6-(benzoylamino)heptanedioic acid, 2-amino-6-[(4-carboxybutanoyl)amino]heptanedioic acid, 2-amino-6-[(4-carboxy-3-methylbutanoyl)amino]heptanedioic acid, 2-amino-6-[(4-carboxy-3,3-dimethylbutanoyl)amino]heptanedioic acid, 2-amino-6-[(4-carboxy-2,2,3,3-tetrafluorobutanoyl)amino]heptanedioic acid, 2-amino-6-[[(2E)-4-methoxy-4-oxobut-2-enoyl]amino]heptanedioic acid, 2-amino-6-[(3-ethoxy-3-oxopropanoyl)amino]heptanedioic acid, and 2-amino-6-[[(2R)-4-methoxy-2-methylpent-4-enoyl]amino]heptanedioic acid	Haemophilus influenzae

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
N-succinyl-LL-2,6-diaminoheptanedioate + H2O	Haemophilus influenzae	-	succinate + LL-2,6-diaminoheptanedioate	-	?

Organism

Organism	UniProt	Comment	Textmining
Haemophilus influenzae	-	gene dapE	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
N-succinyl-LL-2,6-diaminoheptanedioate + H2O	-	Haemophilus influenzae	succinate + LL-2,6-diaminoheptanedioate	-	?

Synonyms

Synonyms	Comment	Organism
DapE	-	Haemophilus influenzae

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
25	-	assay at	Haemophilus influenzae

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.5	-	assay at	Haemophilus influenzae

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
17	-	pH 7.5, 25°C	Haemophilus influenzae	2-amino-6-[(2-methylpropanoyl)amino]heptanedioic acid

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Release 2023.1 (January 2023)