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Literature summary for 3.5.1.127 extracted from

  • Widemann, E.; Miesch, L.; Lugan, R.; Holder, E.; Heinrich, C.; Aubert, Y.; Miesch, M.; Pinot, F.; Heitz, T.
    The amidohydrolases IAR3 and ILL6 contribute to jasmonoyl-isoleucine hormone turnover and generate 12-hydroxyjasmonic acid upon wounding in Arabidopsis leaves (2013), J. Biol. Chem., 288, 31701-31714.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.5.1.127

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Arabidopsis thaliana

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
indole-3-acetic-acid-L-alanine + H2O Arabidopsis thaliana
-
 indole-3-acetic-acid + L-alanine
-
 ?
jasmonoyl-L-isoleucine + H2O Arabidopsis thaliana
-
 jasmonic acid + L-isoleucine
-
 ?

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana
-
-
-
Arabidopsis thaliana Q8VYX0
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
12-hydroxyjasmonoyl-L-isoleucine + H2O
-
 Arabidopsis thaliana 12-hydroxyjasmonic acid + L-isoleucine
-
 ?
indole-3-acetic-acid-L-alanine + H2O
-
 Arabidopsis thaliana indole-3-acetic-acid + L-alanine
-
 ?
jasmonoyl-L-isoleucine + H2O
-
 Arabidopsis thaliana jasmonic acid + L-isoleucine
-
 ?
jasmonoyl-L-isoleucine + H2O 9fold higher activity than with 12-hydroxyjasmonoyl-L-isoleucine Arabidopsis thaliana jasmonic acid + L-isoleucine
-
 ?
additional information no substrates: 12-hydroxyjasmonoyl-L-isoleucine, 12-carboxyjasmonoyl-L-isoleucine Arabidopsis thaliana ?
-
 ?

Synonyms

Synonyms Comment Organism
IAA-amino acid hydrolase ILR1-like 6
-
 Arabidopsis thaliana
IAR3
-
 Arabidopsis thaliana
ILL6
-
 Arabidopsis thaliana

Expression

Organism Comment Expression
Arabidopsis thaliana rapid and transient induction upon wounding up

General Information

General Information Comment Organism
physiological function amidohydrolases IAR3 and ILL6 define a second pathway for jasmonoyl-L-isoleucine turnover during the wound response in Arabidopsis thaliana leaves. The two enzymes cleave the jasmonoyl-L-isoleucine signal, but act also on the tuberonic acid-isoleucine conjugate. The abundant accumulation of tuberonic acid (12-hydroxyjasmonic acid) after wounding originates partly through a sequential pathway involving conjugation of jasmopnic acid to isoleucine, oxidation of the jasmonoyl-L-isoleucine conjugate, and cleavage under the action of the amidohydrolases Arabidopsis thaliana