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Literature summary for 3.5.1.125 extracted from

  • Schwibbert, K.; Marin-Sanguino, A.; Bagyan, I.; Heidrich, G.; Lentzen, G.; Seitz, H.; Rampp, M.; Schuster, S.C.; Klenk, H.P.; Pfeiffer, F.; Oesterhelt, D.; Kunte, H.J.
    A blueprint of ectoine metabolism from the genome of the industrial producer Halomonas elongata DSM 2581 T (2011), Environ. Microbiol., 13, 1973-1994.
    View publication on PubMedView publication on EuropePMC
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Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
36600
-
 x * 36600, calculated Halomonas elongata

Organism

Organism UniProt Comment Textmining
Halomonas elongata E1V7W0
-
-
Halomonas elongata DSM 2581 E1V7W0
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N2-acetyl-L-2,4-diaminobutanoate + H2O
-
 Halomonas elongata L-2,4-diaminobutanoate + acetate
-
 ?
N2-acetyl-L-2,4-diaminobutanoate + H2O
-
 Halomonas elongata DSM 2581 L-2,4-diaminobutanoate + acetate
-
 ?

Subunits

Subunits Comment Organism
? x * 36600, calculated Halomonas elongata

Synonyms

Synonyms Comment Organism
doeB
-
 Halomonas elongata
Helo_3664
-
 Halomonas elongata
N-alpha-acetyl-L-2,4-diaminobutyric acid deacetylase
-
 Halomonas elongata

pI Value

Organism Comment pI Value Maximum pI Value
Halomonas elongata calculated
-
 4.6

General Information

General Information Comment Organism
physiological function the degradation of ectoine proceeds via hydrolysis of ectoine by DoeA to Nalpha-acetyl-L-2,4-diaminobutanoate, followed by deacetylation to diaminobutanoate by DoeB and a transaminase reaction by DoeD leading to aspartate-semialdehyde. Deletion of doeB result in a mutant that cannot utilize ectoine as carbon and nitrogen source. Nalpha-acetyl-L-2,4-diaminobutanoate accumulates as the predominant amino-reactive solute in the mutant while no Nalpha-acetyl-L-2,4-diaminobutanoate is detectable in the wild type Halomonas elongata