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Literature summary for 3.5.1.124 extracted from

  • Richarme, G.; Marguet, E.; Forterre, P.; Ishino, S.; Ishino, Y.
    DJ-1 family Maillard deglycases prevent acrylamide formation (2016), Biochem. Biophys. Res. Commun., 478, 1111-1116.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Escherichia coli P45470
-
-
Homo sapiens Q99497
-
-
Pyrococcus furiosus Q51732
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
an S-(1-hydroxy-2-oxopropyl)-[protein]-L-arginine + H2O
-
Pyrococcus furiosus a [protein]-L-arginine + (R)-lactate
-
?
an S-(1-hydroxy-2-oxopropyl)-[protein]-L-arginine + H2O
-
Homo sapiens a [protein]-L-arginine + (R)-lactate
-
?
an S-(1-hydroxy-2-oxopropyl)-[protein]-L-arginine + H2O
-
Escherichia coli a [protein]-L-arginine + (R)-lactate
-
?
an S-(1-hydroxy-2-oxopropyl)-[protein]-L-cysteine + H2O
-
Pyrococcus furiosus a [protein]-L-cysteine + (R)-lactate
-
?
an S-(1-hydroxy-2-oxopropyl)-[protein]-L-cysteine + H2O
-
Homo sapiens a [protein]-L-cysteine + (R)-lactate
-
?
an S-(1-hydroxy-2-oxopropyl)-[protein]-L-cysteine + H2O
-
Escherichia coli a [protein]-L-cysteine + (R)-lactate
-
?
an S-(1-hydroxy-2-oxopropyl)-[protein]-L-lysine + H2O
-
Pyrococcus furiosus a [protein]-L-lysine + (R)-lactate
-
?
an S-(1-hydroxy-2-oxopropyl)-[protein]-L-lysine + H2O
-
Homo sapiens a [protein]-L-lysine + (R)-lactate
-
?
an S-(1-hydroxy-2-oxopropyl)-[protein]-L-lysine + H2O
-
Escherichia coli a [protein]-L-lysine + (R)-lactate
-
?

Synonyms

Synonyms Comment Organism
deglycase
-
Pyrococcus furiosus
deglycase
-
Homo sapiens
deglycase
-
Escherichia coli
DJ-1
-
Homo sapiens
Maillard deglycase
-
Pyrococcus furiosus
Maillard deglycase
-
Homo sapiens
Maillard deglycase
-
Escherichia coli
PARK7
-
Homo sapiens
PfpI
-
Pyrococcus furiosus
yhbO
-
Escherichia coli

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
55
-
assay at Homo sapiens
70
-
assay at Escherichia coli
70
-
assay at, deglycase activity Pyrococcus furiosus

Temperature Range [°C]

Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
55 95 enzyme activity is reduced by 72% for YhbO 70°C, YhbO is inactive at 95°C Escherichia coli
55 95 enzyme activity is reduced by 74% for DJ-1 at 70°C, DJ-1 is inactive at 95°C Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
assay at Pyrococcus furiosus
7
-
assay at Homo sapiens
7
-
assay at Escherichia coli

General Information

General Information Comment Organism
evolution the enzyme PfpI belongs to the PfpI/Hsp31/DJ-1 superfamily Pyrococcus furiosus
physiological function the enzyme prevents acrylamide formation in vivo, acrylamide formation in the glyoxal/asparagine mixture is reduced by 72% by PfpI Pyrococcus furiosus
physiological function the enzyme prevents acrylamide formation in vivo, acrylamide formation in the glyoxal/asparagine mixture is reduced by 78% by YhbO Escherichia coli
physiological function the enzyme prevents acrylamide formation in vivo, acrylamide formation in the glyoxal/asparagine mixture is reduced by 98% by DJ-1 Homo sapiens