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Literature summary for 3.5.1.121 extracted from

  • Hirai, T.; Taniura, H.; Goto, Y.; Ogura, M.; Sng, J.; Yoneda, Y.
    Stimulation of ubiquitin-proteasome pathway through the expression of amidohydrolase for N-terminal asparagine (Ntan1) in cultured rat hippocampal neurons exposed to static magnetism (2006), J. Neurochem., 96, 1519-1530.
    View publication on PubMed
Search for more literature for 3.5.1.121

Cloned(Commentary)

Cloned (Comment) Organism
gene Ntan1, rat Ntan1 promoter (-1361 to +99) is prepared from rat genomic DNA by PCR, sequence comparisons, overexpression of Ntan1 using recombinant Ntan1 adenovirus vector resulting in a marked decrease in the MAP2 protein expression in hippocampal neurons Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
N-terminal L-asparaginyl-[protein] + H2O Rattus norvegicus
-
 N-terminal L-aspartyl-[protein] + NH3
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Rattus norvegicus
-
cell culture
-
 Rattus norvegicus
-
hippocampus
-
 Rattus norvegicus
-
neuron hippocampal neurons Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-terminal L-asparaginyl-[protein] + H2O
-
 Rattus norvegicus N-terminal L-aspartyl-[protein] + NH3
-
 ?

Synonyms

Synonyms Comment Organism
amidohydrolase for N-terminal asparagine
-
 Rattus norvegicus
NTAN1
-
 Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus gene Ntan1 mRNA is increased about 3fold after 3 h in response to brief magnetism. Brief magnetism also increases the transcriptional activity of Ntan1 promoter by luciferase reporter assay up

General Information

General Information Comment Organism
metabolism the enzyme is involved in the mammalian N-end rule pathway Rattus norvegicus
physiological function Ntan1 (amidohydrolase for N-terminal asparagine) is a magnetism responsive gene in rat brain. Ntan1 is an essential component of a protein degradation signal, which is a destabilizing N-terminal residue of a protein, in the N-end rule. Overexpression of gene Ntan1 results in a marked decrease in the MAP2 protein expression in hippocampal neurons. Brief magnetism leads to the induction of Ntan1 responsible for MAP2 protein degradation through ubiquitin-proteasome pathway in rat hippocampal neurons Rattus norvegicus