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Literature summary for 3.5.1.121 extracted from

  • Balogh, S.; McDowell, C.; Tae Kwon, Y.; Denenberg, V.
    Facilitated stimulus-response associative learning and long-term memory in mice lacking the NTAN1 amidase of the N-end rule pathway (2001), Brain Res., 892, 336-343.
    View publication on PubMed
Search for more literature for 3.5.1.121

Protein Variants

Protein Variants Comment Organism
additional information generation of enzyme-deficient NTAN1-/- mice Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
N-terminal L-asparaginyl-[protein] + H2O Mus musculus
-
 N-terminal L-aspartyl-[protein] + NH3
-
 ?
N-terminal L-asparaginyl-[protein] + H2O Mus musculus 129
-
 N-terminal L-aspartyl-[protein] + NH3
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q64311
-
-
Mus musculus 129 Q64311
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-terminal L-asparaginyl-[protein] + H2O
-
 Mus musculus N-terminal L-aspartyl-[protein] + NH3
-
 ?
N-terminal L-asparaginyl-[protein] + H2O
-
 Mus musculus 129 N-terminal L-aspartyl-[protein] + NH3
-
 ?

Synonyms

Synonyms Comment Organism
NTAN1 amidase
-
 Mus musculus

General Information

General Information Comment Organism
malfunction NTAN1-deficient mice are better than wild-type mice on black-white and horizontal-vertical discrimination learning. They are also better at 8-week Morris maze retention testing when a reversal trial is not included in the testing procedures. In all three tasks NTAN1-deficient mice appear to use a strong win-stay strategy. It is concluded that inactivating the asparagine-specific branch of the N-end rule pathway in mice results in impaired spatial learning with concomitant compensatory restructuring of the nervous system in favor of non-spatial (stimulus-response) learning Mus musculus
metabolism the enzyme is involved in the mammalian N-end rule pathway, overview Mus musculus