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Literature summary for 3.5.1.12 extracted from

  • Evangelatos, S.A.; Kakabakos, S.E.; Evangelatos, G.P.; Ithakissios, D.S.
    Determination of serum biotinidase activity with biotinyl derivatives of iodotyramines as substrates (1993), J. Pharm. Sci., 82, 1228-1231.
    View publication on PubMed
Search for more literature for 3.5.1.12

Application

Application Comment Organism
medicine plasma biotinidase activity assay for diagnosis and screen newborn infants for biotinidase deficiency, treatment of inborn metabolism errors with large doses of biotin Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0158
-
 biotinyl-monoiodotyramine
-
 Homo sapiens
0.0259
-
 biotinyl-di-iodotyramine
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
biotin amide + H2O Homo sapiens
-
 ?
-
 ?
epsilon-N-biotinyl-L-lysine + H2O Homo sapiens
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 human
-

Source Tissue

Source Tissue Comment Organism Textmining
blood serum, plasma, leukocytes Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
biotin amide + H2O
-
 Homo sapiens ?
-
 ?
biotinyl-di-iodotyramine + H2O radioactive assay for early diagnosis of biotinidase defiency in serum Homo sapiens biotin + di-iodotyramine
-
 ?
biotinyl-monoiodotyramine + H2O radioactive assay for early diagnosis of biotinidase defiency in serum Homo sapiens biotin + monoiodotyramine
-
 ?
epsilon-N-biotinyl-L-lysine + H2O
-
 Homo sapiens biotin + L-lysine
-
 ir
epsilon-N-biotinyl-L-lysine + H2O
-
 Homo sapiens ?
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6 6.8
-
 Homo sapiens