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Literature summary for 3.5.1.119 extracted from

  • Striebel, F.; Imkamp, F.; ึzcelik, D.; Weber-Ban, E.
    Pupylation as a signal for proteasomal degradation in bacteria (2014), Biochim. Biophys. Acta, 1843, 103-113.
    View publication on PubMed
Search for more literature for 3.5.1.119

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
[prokaryotic ubiquitin-like protein]-L-glutamine + H2O Mycobacterium tuberculosis deamidase (Dop) renders prokaryotic ubiquitin-like protein Pup competent for conjugation to substrates, which is then carried out by the Pup-ligase PafA. Pupylation is a signal for proteasomal degradation in bacteria [prokaryotic ubiquitin-like protein]-L-glutamate + NH3
-
 ?
[prokaryotic ubiquitin-like protein]-L-glutamine + H2O Mycobacterium tuberculosis ATCC 25618 deamidase (Dop) renders prokaryotic ubiquitin-like protein Pup competent for conjugation to substrates, which is then carried out by the Pup-ligase PafA. Pupylation is a signal for proteasomal degradation in bacteria [prokaryotic ubiquitin-like protein]-L-glutamate + NH3
-
 ?

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis P9WNU9
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-
Mycobacterium tuberculosis ATCC 25618 P9WNU9
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-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N6-([prokaryotic ubiquitin-like protein]-gamma-L-glutamyl)-[protein]-L-lysine + H2O the enzyme catalyzes the nucleophilic attack of water on the terminal carbonyl atom of Pup, releasing ammonium in the case of deamidation or the substrate lysine in case of depupylation Mycobacterium tuberculosis [prokaryotic ubiquitin-like protein]-L-glutamate + [protein]-L-lysine
-
 ?
N6-([prokaryotic ubiquitin-like protein]-gamma-L-glutamyl)-[protein]-L-lysine + H2O the enzyme catalyzes the nucleophilic attack of water on the terminal carbonyl atom of Pup, releasing ammonium in the case of deamidation or the substrate lysine in case of depupylation Mycobacterium tuberculosis ATCC 25618 [prokaryotic ubiquitin-like protein]-L-glutamate + [protein]-L-lysine
-
 ?
[prokaryotic ubiquitin-like protein]-L-glutamine + H2O deamidase (Dop) renders prokaryotic ubiquitin-like protein Pup competent for conjugation to substrates, which is then carried out by the Pup-ligase PafA. Pupylation is a signal for proteasomal degradation in bacteria Mycobacterium tuberculosis [prokaryotic ubiquitin-like protein]-L-glutamate + NH3
-
 ?
[prokaryotic ubiquitin-like protein]-L-glutamine + H2O the deamidase activity (Dop) renders prokaryotic ubiquitin-like protein Pup competent for conjugation to substrates, which is then carried out by the Pup-ligase PafA. The enzyme catalyzes the nucleophilic attack of water on the terminal carbonyl atom of Pup, releasing ammonium in the case of deamidation or the substrate lysine in case of depupylation Mycobacterium tuberculosis [prokaryotic ubiquitin-like protein]-L-glutamate + NH3
-
 ?
[prokaryotic ubiquitin-like protein]-L-glutamine + H2O deamidase (Dop) renders prokaryotic ubiquitin-like protein Pup competent for conjugation to substrates, which is then carried out by the Pup-ligase PafA. Pupylation is a signal for proteasomal degradation in bacteria Mycobacterium tuberculosis ATCC 25618 [prokaryotic ubiquitin-like protein]-L-glutamate + NH3
-
 ?
[prokaryotic ubiquitin-like protein]-L-glutamine + H2O the deamidase activity (Dop) renders prokaryotic ubiquitin-like protein Pup competent for conjugation to substrates, which is then carried out by the Pup-ligase PafA. The enzyme catalyzes the nucleophilic attack of water on the terminal carbonyl atom of Pup, releasing ammonium in the case of deamidation or the substrate lysine in case of depupylation Mycobacterium tuberculosis ATCC 25618 [prokaryotic ubiquitin-like protein]-L-glutamate + NH3
-
 ?

Synonyms

Synonyms Comment Organism
depupylase
-
 Mycobacterium tuberculosis
depupylase/deamidase
-
 Mycobacterium tuberculosis
Dop
-
 Mycobacterium tuberculosis
Rv2112c locus name Mycobacterium tuberculosis

General Information

General Information Comment Organism
physiological function the enzyme is involved in pupylation. Pupylation is a signal for proteasomal degradation in bacteria Mycobacterium tuberculosis