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Literature summary for 3.5.1.115 extracted from
- Synthesis of a bromotyrosine-derived natural product inhibitor of mycothiol-S-conjugate amidase (2004), Bioorg. Med. Chem. Lett., 14, 3785-3788.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| bromotyrosine oxime | - |
Mycobacterium tuberculosis |  |
| hemibastidin-2 | - |
Mycobacterium tuberculosis | |
| psammaplin A | - |
Mycobacterium tuberculosis | |
| verongamine | - |
Mycobacterium tuberculosis | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| a mycothiol S-conjugate + H2O | Mycobacterium tuberculosis | - |
an N-acetyl L-cysteine-S-conjugate + 1-O-(2-amino-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mycobacterium tuberculosis | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| a mycothiol S-conjugate + H2O | - |
Mycobacterium tuberculosis | an N-acetyl L-cysteine-S-conjugate + 1-O-(2-amino-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| MCA | - |
Mycobacterium tuberculosis |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.03 | - |
pH and temperature not specified in the publication | Mycobacterium tuberculosis | bromotyrosine oxime | |
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