Literature summary for 3.5.1.109 extracted from

Hara, J.; Higuchi, K.; Okamoto, R.; Kawashima, M.; Imokawa, G.
High-expression of sphingomyelin deacylase is an important determinant of ceramide deficiency leading to barrier disruption in atopic dermatitis (2000), J. Invest. Dermatol., 115, 406-413.

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	patients with atopic dermatitis	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
epidermis	in extracts of whole epidermis biopsies from patients with atopic dermatitis, sphingomyelin deacylase activities are significantly (3-fold) increased over healthy controls in the particulate fraction, whereas there is no significant difference in the activity of sphingomyelinase between atopic dermatitis and healthy control	Homo sapiens	-
lymphocyte	in peripheral blood lymphocytes of patients with atopic dermatitis, there is no increase in activity compared with healthy controls	Homo sapiens	-
stratum corneum	from lesional forearm skin (volar side) of patients with atopic dermatitis, sphingomyelin deacylase activity is at least 5times higher than in the stratum corneum of healthy controls. In stratum corneum from nonlesional skin of patients with atopic dermatitis, SM deacylase activity is at least three times higher than in healthy controls. Stratum corneum from contact dermatitis patients shows levels of sphingomyelin deacylase similar to healthy controls	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
16-(9-anthroyloxy)hexadecanoyl-sphingosylphosphorylcholine + H2O	-	Homo sapiens	16-(9-anthroyloxy)hexadecanoic acid + sphingosylphosphorylcholine	-	?
N-palmitoyl-sphingosylphosphorylcholine + H2O	-	Homo sapiens	palmitic acid + sphingosylphosphorylcholine	-	?

Synonyms

Synonyms	Comment	Organism
SM deacylase	-	Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
37	-	assay at	Homo sapiens

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
4.7	-	assay at	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	high-expression of sphingomyelin deacylase is an important determinant of ceramide deficiency leading to barrier disruption in atopic dermatitis. The enzyme is highly expressed in the epidermis of patients with atopic dermatitis, and competes with sphingomyelinase or beta-glucocerebrosidase for the common substrate sphingomyelin or glucosylceramide, which leads to the ceramide deficiency of the stratum corneum in atopic dermatitis	Homo sapiens

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Release 2023.1 (January 2023)