Literature summary for 3.5.1.105 extracted from

Hirano, T.; Okubo, M.; Tsuda, H.; Yokoyama, M.; Hakamata, W.; Nishio, T.
Chitin heterodisaccharide, released from chitin by chitinase and chitin oligosaccharide deacetylase, enhances the chitin-metabolizing ability of Vibrio parahaemolyticus (2019), J. Bacteriol., 201, e00270-19 .

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Cloned(Commentary)

Cloned (Comment)	Organism
gene VP2638, quantitative real-time PCR expression analysis	Vibrio parahaemolyticus RIMD 2210633

Organism

Organism	UniProt	Comment	Textmining
Vibrio parahaemolyticus RIMD 2210633	Q87LH9	serotype O3:K6	-

Synonyms

Synonyms	Comment	Organism
chitin disaccharide deacetylase	-	Vibrio parahaemolyticus RIMD 2210633
chitin oligosaccharide deacetylase	-	Vibrio parahaemolyticus RIMD 2210633
COD	-	Vibrio parahaemolyticus RIMD 2210633
VP2638	-	Vibrio parahaemolyticus RIMD 2210633

Expression

Organism	Comment	Expression
Vibrio parahaemolyticus RIMD 2210633	COD, encoded by gene VP2638, is detected at a high coverage in the culture supernatant, and its expression appears to be induced by disaccharides over 50fold	up

General Information

General Information	Comment	Organism
metabolism	Vibrio parahaemolyticus strain RIMD 2210633 secretes both chitinase and chitin oligosaccharide deacetylase (COD) and produces beta-N-acetyl-D-glucosaminyl-(1,4)-D-glucosamine (GlcNAc-GlcN) from chitin. GlcNAc-GlcN induces chitinase production by several strains of Vibrio harboring chitin oligosaccharide deacetylase genes. Enzyme chitin oligosaccharide deacetylase is involved in the Vibrio chitin degradation system degrading N,N'-diacetylchitobiose, a homodisaccharide produced from chitin, which is known to induce the expression of genes encoding several proteins involved in chitin metabolism in Vibrio strains. (GlcNAc)2 is deacetylated to GlcNAc-GlcN by COD	Vibrio parahaemolyticus RIMD 2210633
additional information	examination of the induction of protein expression by several sugars released from chitin using peptide mass fingerprinting and confirming the expression of genes encoding enzymes involved in chitin metabolism using real-time quantitative PCR analysis, detailed overview	Vibrio parahaemolyticus RIMD 2210633
physiological function	the enzyme hydrolyzes the N-acetyl group at the reducing-end GlcNAc residue of (GlcNAc)2 to generate the heterodisaccharide beta-N-acetyl-D-glucosaminyl-(1,4)-D-glucosamine (GlcNAc-GlcN)	Vibrio parahaemolyticus RIMD 2210633

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Release 2023.1 (January 2023)