Literature summary for 3.5.1.104 extracted from

Fittipaldi, N.; Sekizaki, T.; Takamatsu, D.; Dominguez-Punaro Mde, L.; Harel, J.; Bui, N.K.; Vollmer, W.; Gottschalk M.
Significant contribution of the pgdA gene to the virulence of Streptococcus suis (2008), Mol. Microbiol., 70, 1120-1135.

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Organism

Organism	UniProt	Comment	Textmining
Streptococcus suis	-	-	-

Synonyms

Synonyms	Comment	Organism
pgdA	-	Streptococcus suis

Expression

Organism	Comment	Expression
Streptococcus suis	expression of the pgdA gene is increased upon interaction of the bacterium with neutrophils in vitro as well as in vivo in experimentally inoculated mice	up

General Information

General Information	Comment	Organism
malfunction	evaluation of the DELTApgdA mutant in both the CD1 murine and the porcine models of infection reveals a significant contribution of the pgdA gene to the virulence traits of Streptococcus suis. Reflecting a severe impairment in its ability to persist in blood and decreased ability to escape immune clearance mechanisms mediated by neutrophils, the DELTApgdA mutant is highly attenuated in both models. The results of this study suggest that modification of peptidoglycan by N-deacetylation is an important factor in Streptococcus suis virulence	Streptococcus suis

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Release 2023.1 (January 2023)