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Literature summary for 3.5.1.103 extracted from

  • Nicholas, G.M.; Eckman, L.L.; Kovac, P.; Otero-Quintero, S.; Bewley, C.A.
    Synthesis of 1-D- and 1-L-myo-inosityl 2-N-acetamido-2-deoxy-alpha-D-glucopyranoside establishes substrate specificity of the Mycobacterium tuberculosis enzyme AcGI deacetylase (2003), Bioorg. Med. Chem., 11, 2641-2647.
    View publication on PubMed
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Cloned(Commentary)

Cloned (Comment) Organism
-
 Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol + H2O Mycobacterium tuberculosis biosynthesis of mycothiol 1-(2-amino-2-deoxy-alpha-D-glucopyranoside)-1D-myo-inositol + acetate
-
 ?
1-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol + H2O Mycobacterium tuberculosis H37Rv biosynthesis of mycothiol 1-(2-amino-2-deoxy-alpha-D-glucopyranoside)-1D-myo-inositol + acetate
-
 ?

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis P9WJN3
-
-
Mycobacterium tuberculosis H37Rv P9WJN3
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-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol + H2O biosynthesis of mycothiol Mycobacterium tuberculosis 1-(2-amino-2-deoxy-alpha-D-glucopyranoside)-1D-myo-inositol + acetate
-
 ?
1-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol + H2O the enzyme is specific for 1-D-myo-inosityl 2-N-acetamido-2-deoxy-alpha-D-glucopyranoside Mycobacterium tuberculosis 1-(2-amino-2-deoxy-alpha-D-glucopyranoside)-1D-myo-inositol + acetate
-
 ?
1-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol + H2O biosynthesis of mycothiol Mycobacterium tuberculosis H37Rv 1-(2-amino-2-deoxy-alpha-D-glucopyranoside)-1D-myo-inositol + acetate
-
 ?
1-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol + H2O the enzyme is specific for 1-D-myo-inosityl 2-N-acetamido-2-deoxy-alpha-D-glucopyranoside Mycobacterium tuberculosis H37Rv 1-(2-amino-2-deoxy-alpha-D-glucopyranoside)-1D-myo-inositol + acetate
-
 ?

Synonyms

Synonyms Comment Organism
1-D-myo-inosityl 2-N-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase
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 Mycobacterium tuberculosis
AcGI deacetylase
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 Mycobacterium tuberculosis

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
32
-
 assay at Mycobacterium tuberculosis

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Mycobacterium tuberculosis