Application | Comment | Organism |
---|---|---|
medicine | L-asparaginase is important in the induction regimen for treating human acute lymphoblastic leukemia, cytotoxic complications are clinically significant problems lacking mechanistic insight, the enzyme is used in the treatment of both pediatric and adult forms of acute lymphoblastic leukemia, ALL | Escherichia coli |
medicine | L-asparaginase is important in the induction regimen for treating human acute lymphoblastic leukemia, cytotoxic complications are clinically significant problems lacking mechanistic insight, the enzyme is used in the treatment of both pediatric andadult forms of acute lymphoblastic leukemia, ALL | Wolinella succinogenes |
Protein Variants | Comment | Organism |
---|---|---|
additional information | applicated to mice, the enzyme abolishes serum asparagine and glutamine, and reduces protein synthesis in liver, and spleen, but not in pancreas via increase dephosphorylation of the translation factor eIF2, overview | Escherichia coli |
additional information | applicated to mice, the enzyme abolishes serum asparagine, but not glutamine, the enzyme does not alter protein synthesis, overview | Wolinella succinogenes |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-asparagine + H2O | Escherichia coli | - |
L-aspartate + NH3 | - |
? | |
L-asparagine + H2O | Wolinella succinogenes | - |
L-aspartate + NH3 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Wolinella succinogenes | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Wolinella succinogenes |
further purification of the commercial preparation by gel filtration to remove endotoxin | Escherichia coli |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
commercial preparation | - |
Escherichia coli | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-asparagine + H2O | - |
Escherichia coli | L-aspartate + NH3 | - |
? | |
L-asparagine + H2O | - |
Wolinella succinogenes | L-aspartate + NH3 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
L-asparaginase | - |
Escherichia coli |
L-asparaginase | - |
Wolinella succinogenes |