Literature summary for 3.4.25.2 extracted from

Lee, J.W.; Park, E.; Bang, O.; Eom, S.H.; Cheong, G.W.; Chung, C.H.; Seol, J.H.
Nucleotide triphosphates inhibit the degradation of unfolded proteins by HslV peptidase (2007), Mol. Cell, 23, 252-257.

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Protein Variants

Protein Variants	Comment	Organism
R86G	ATP inhibits the degradation of unfolded proteins by HslV. This inhibitory effect of ATP is markedly diminished by substitution of the Arg86 residue located in the apical pore of HslV with Gly	Escherichia coli

Inhibitors

Inhibitors	Comment	Organism	Structure
ATP	inhibits the degradation of unfolded proteins by HslV	Escherichia coli

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
unfolded lactalbumin + H2O	HslV alone can efficiently degrade certain unfolded proteins, such as unfolded lactalbumin and lysozyme prepared by complete reduction of disulfide bonds, but not their native forms. HslV alone cleaves a lactalbumin fragment sandwiched by two thioredoxin molecules, indicating that it can hydrolyze the internal peptide bonds of lactalbumin. Uncomplexed HslV is inactive under normal conditions, but can degrade unfolded proteins when the ATP level is low, as it is during carbon starvation	Escherichia coli	?	-	?
unfolded lysozyme + H2O	HslV alone can efficiently degrade certain unfolded proteins, such as unfolded lactalbumin and lysozyme prepared by complete reduction of disulfide bonds, but not their native forms. HslV alone cleaved a lactalbumin fragment sandwiched by two thioredoxin molecules, indicating that it can hydrolyze the internal peptide bonds of lactalbumin. Uncomplexed HslV is inactive under normal conditions, but can degrade unfolded proteins when the ATP level is low, as it is during carbon starvation	Escherichia coli	?	-	?

Synonyms

Synonyms	Comment	Organism
hslVU	ATP-dependent protease consisting of two heat shock proteins, the HslU ATPase and HslV peptidase	Escherichia coli

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Release 2023.1 (January 2023)