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Literature summary for 3.4.25.1 extracted from

  • Zheng, J.; Bizzozero, O.A.
    Reduced proteasomal activity contributes to the accumulation of carbonylated proteins in chronic experimental autoimmune encephalomyelitis (2010), J. Neurochem., 115, 1556-1567.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
calpeptin inhibits calpain-like activity Mus musculus
clastolactacystin-beta-lactone
-
Mus musculus
epoxomicin inhibits trypsin-like activity Mus musculus
NH4Cl lysosomal inhibitor Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
eight-week-old female mice
-
Mus musculus C57BL/6
-
eight-week-old female mice
-

Source Tissue

Source Tissue Comment Organism Textmining
astrocyte differentiated from C6 glioma cells Mus musculus
-
brain
-
Mus musculus
-
cerebellum
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Boc-Leu-Arg-Arg-7-amido-4-methylcoumarin + H2O for trypsin-like activity Mus musculus ?
-
?
Boc-Leu-Arg-Arg-7-amido-4-methylcoumarin + H2O for trypsin-like activity Mus musculus C57BL/6 ?
-
?
Suc-Leu-Leu-Val-Tyr-7-amido-4-methylcoumarin + H2O for chymotrypsin-like activity Mus musculus ?
-
?
Suc-Leu-Leu-Val-Tyr-7-amido-4-methylcoumarin + H2O for chymotrypsin-like activity Mus musculus C57BL/6 ?
-
?
Z-Leu-Leu-Glu-7-amido-4-methylcoumarin + H2O for caspase-like activity Mus musculus Z-Leu-Leu-Glu + 7-amino-4-methylcoumarin
-
?
Z-Leu-Leu-Glu-7-amido-4-methylcoumarin + H2O for caspase-like activity Mus musculus C57BL/6 Z-Leu-Leu-Glu + 7-amino-4-methylcoumarin
-
?
Z-Leu-Leu-Val-Tyr-7-amido-4-methylcoumarin + H2O for calpain-like activity Mus musculus Z-Leu-Leu-Val-Tyr + 7-amino-4-methylcoumarin
-
?
Z-Leu-Leu-Val-Tyr-7-amido-4-methylcoumarin + H2O for calpain-like activity Mus musculus C57BL/6 Z-Leu-Leu-Val-Tyr + 7-amino-4-methylcoumarin
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
assay at Mus musculus

General Information

General Information Comment Organism
malfunction reduced proteasomal activity contributes to the accumulation of carbonylated proteins in chronic experimental autoimmune encephalomyelitis. Chymotrysin-like and caspase-like activities of the 20S proteasome are impaired in chronic experimental autoimmune encephalomyelitis, while the amount of proteasome is unchanged, determination of proteasome failure by the build-up of ubiquitinated proteins, mostly within astrocytes, diminished activity of the 20S proteasome is a major contributor to the accumulation of carbonylated proteins in astrocytes of chronic experimental autoimmune encephalomyelitis mice Mus musculus