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Literature summary for 3.4.25.1 extracted from

  • Radhakrishnan, S.K.; Lee, C.S.; Young, P.; Beskow, A.; Chan, J.Y.; Deshaies, R.J.
    Transcription factor Nrf1 mediates the proteasome recovery pathway after proteasome inhibition in mammalian cells (2010), Mol. Cell, 38, 17-28.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.25.1

Activating Compound

Activating Compound Comment Organism Structure
nuclear factor erythroid-derived 2-related factor 1 i.e. Nrf1, a transcription factor of the cap and collar basic leucine zipper family, but not the related Nrf2, is necessary for induced proteasome gene transcription in cancer cell lines, overview Homo sapiens
nuclear factor erythroid-derived 2-related factor 1 i.e. Nrf1, a transcription factor of the cap and collar basic leucine zipper family, but not the related Nrf2, is necessary for induced proteasome gene transcription in mouse embryonic fibroblasts, overview. Knockdown of Nrf1 in wild-type mouse embryonic fibroblasts abolishes MG132-mediated upregulation of RNA levels of PSM genes Mus musculus

Application

Application Comment Organism
medicine Nrf1-mediated proteasome homeostasis can be an attractive target for therapeutic intervention in cancer Mus musculus
medicine Nrf1-mediated proteasome homeostasis can be an attractive target for therapeutic intervention in cancer Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
bortezomib
-
 Homo sapiens
MG132
-
 Homo sapiens
Yu101
-
 Homo sapiens
Yu101 Nrf1-/- mouse embryonic fibroblasts are impaired in the recovery of proteasome activity after transient treatment with the covalent proteasome inhibitor YU101 Mus musculus

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
embryonic fibroblast
-
 Mus musculus
-
HT-29 cell colon cancer cell line Homo sapiens
-
LNCaP cell prostate cancer cell line Homo sapiens
-
MDA-MB-231 cell breast cancer cell line Homo sapiens
-
U2-OS cell osteosarcoma cell line Homo sapiens
-

Synonyms

Synonyms Comment Organism
26S proteasome
-
 Mus musculus
26S proteasome
-
 Homo sapiens
proteasome
-
 Mus musculus
proteasome
-
 Homo sapiens

Expression

Organism Comment Expression
Mus musculus importance of antioxidant response elements in Nrf1-mediated upregulation of proteasome subunit genes up
Homo sapiens importance of antioxidant response elements in Nrf1-mediated upregulation of proteasome subunit genes up

General Information

General Information Comment Organism
additional information proteasome inhibitors, but not a Nedd8 pathway inhibitor, upregulate RNA levels of PSM genes in cancer cells Homo sapiens