Activating Compound | Comment | Organism | Structure |
---|---|---|---|
19S regulatory complex | represents the major proteasome activator | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
bortezomib | - |
Homo sapiens | |
MG132 | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | proteasome status in KG1a and U937 cells, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
acute myeloid leukemia cell | primary cells, and cell lines | Homo sapiens | - |
KG-1A cell | - |
Homo sapiens | - |
U-937 cell | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
29 | - |
chymotrypsin-like activity, KG1a cells, pH 7.4, 22°C | Homo sapiens |
71 | - |
chymotrypsin-like activity, U-937 cells, pH 7.4, 22°C | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | proteasome status in KG1a and U937 cells, overview | Homo sapiens | ? | - |
? | |
additional information | proteasome complexes possess three main catalytic activities, which are trypsin-like, chymotrypsin-like, and caspase-like | Homo sapiens | ? | - |
? | |
N-succinyl-LLVY-7-amido-4-methylcoumarin + H2O | chymotrypsin-like proteasome activity | Homo sapiens | N-succinyl-LLVY + 7-amino-4-methylcoumarin | - |
? |
Synonyms | Comment | Organism |
---|---|---|
20S proteasome | - |
Homo sapiens |
26S proteasome | - |
Homo sapiens |
proteasome | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
22 | - |
in vivo assay at room temperature | Homo sapiens |
37 | - |
in vitroo assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |