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Literature summary for 3.4.25.1 extracted from

  • Matondo, M.; Bousquet-Dubouch, M.P.; Gallay, N.; Uttenweiler-Joseph, S.; Recher, C.; Payrastre, B.; Manenti, S.; Monsarrat, B.; Burlet-Schiltz, O.
    Proteasome inhibitor-induced apoptosis in acute myeloid leukemia: a correlation with the proteasome status (2010), Leuk. Res., 34, 498-506.
    View publication on PubMed
Search for more literature for 3.4.25.1

Activating Compound

Activating Compound Comment Organism Structure
19S regulatory complex represents the major proteasome activator Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
bortezomib
-
 Homo sapiens
MG132
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens proteasome status in KG1a and U937 cells, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
acute myeloid leukemia cell primary cells, and cell lines Homo sapiens
-
KG-1A cell
-
 Homo sapiens
-
U-937 cell
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
29
-
 chymotrypsin-like activity, KG1a cells, pH 7.4, 22°C Homo sapiens
71
-
 chymotrypsin-like activity, U-937 cells, pH 7.4, 22°C Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information proteasome status in KG1a and U937 cells, overview Homo sapiens ?
-
 ?
additional information proteasome complexes possess three main catalytic activities, which are trypsin-like, chymotrypsin-like, and caspase-like Homo sapiens ?
-
 ?
N-succinyl-LLVY-7-amido-4-methylcoumarin + H2O chymotrypsin-like proteasome activity Homo sapiens N-succinyl-LLVY + 7-amino-4-methylcoumarin
-
 ?

Synonyms

Synonyms Comment Organism
20S proteasome
-
 Homo sapiens
26S proteasome
-
 Homo sapiens
proteasome
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
22
-
 in vivo assay at room temperature Homo sapiens
37
-
 in vitroo assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Homo sapiens