Literature summary for 3.4.25.1 extracted from

Seeger, J.M.; Schmidt, P.; Brinkmann, K.; Hombach, A.A.; Coutelle, O.; Zigrino, P.; Wagner-Stippich, D.; Mauch, C.; Abken, H.; Kroenke, M.; Kashkar, H.
The proteasome inhibitor bortezomib sensitizes melanoma cells toward adoptive CTL attack (2010), Cancer Res., 70, 1825-1834.

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Inhibitors

Inhibitors	Comment	Organism	Structure
bortezomib	the proteasome inhibitor bortezomib sensitizes previously resistant tumor cells, melanoma cells, for cytolytic T-cell attack	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
melanoma cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
proteasome	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	proteasome inhibition increases the sensitivity of tumor cells toward cytolytic T-cell attack by NOXA-mediated enhancement of mitochondrial second mitochondria-derived activator of caspase, SMAC, release, overview	Homo sapiens

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Release 2023.1 (January 2023)