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Literature summary for 3.4.25.1 extracted from

  • Amici, M.; Sagratini, D.; Pettinari, A.; Pucciarelli, S.; Angeletti, M.; Eleuteri, A.M.
    20S proteasome mediated degradation of DHFR: implications in neurodegenerative disorders (2004), Arch. Biochem. Biophys., 422, 168-174.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
dihydrofolate reductase + H2O Bos taurus directly hydrolyzed by the 20S complex, without any previous ubiquitination. The degradation is increased under oxidative conditions. The folate metabolism may be impaired by an increased degradation of dihydrofolate reductase, mediated by the 20S proteasome ?
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?

Organism

Organism UniProt Comment Textmining
Bos taurus
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
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Bos taurus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dihydrofolate reductase + H2O directly hydrolyzed by the 20S complex, without any previous ubiquitination. The degradation is increased under oxidative conditions. The folate metabolism may be impaired by an increased degradation of dihydrofolate reductase, mediated by the 20S proteasome Bos taurus ?
-
?
dihydrofolate reductase + H2O directly hydrolyzed by the 20S complex, without any previous ubiquitination. The degradation is increased under oxidative conditions Bos taurus ?
-
?