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Literature summary for 3.4.24.B7 extracted from

  • Park, H.I.; Turk, B.E.; Gerkema, F.E.; Cantley, L.C.; Sang, Q.X.
    Peptide substrate specificities and protein cleavage sites of human endometase/matrilysin-2/matrix metalloproteinase-26 (2002), J. Biol. Chem., 277, 35168-35175.
    View publication on PubMed
Search for more literature for 3.4.24.B7

Inhibitors

Inhibitors Comment Organism Structure
(3R)-N-hydroxy-2-[(4-methoxyphenyl)sulfonyl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide
-
 Homo sapiens
(3S)-N-hydroxy-2-[(4-methoxyphenyl)sulfonyl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide
-
 Homo sapiens
4-Aminobenzoyl-Gly-Pro-D-Leu-D-Ala-NHOH
-
 Homo sapiens
N-[(2R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl]-L-tryptophan i.e. GM6001 Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ a zinc metalloproteinase Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification two of the major autolytic sites are Leu49–/-Thr50 and Ala75–/-Leu76, which still left the cysteine switch sequence intact Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(7-methoxycoumarin)-4-yl-acetyl-Pro-Leu-Ala-Nva-(N-3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl)-Ala-Arg-NH2 + H2O among the fluorescent peptide substrates analyzed, 7-amido-4-methylcoumaryl-Pro-Leu-Ala-Nva-(N-3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl)-Ala-Arg-NH2 displays the highest specificity constant Homo sapiens (7-methoxycoumarin)-4-yl-acetyl-Pro-Leu-Ala + Nva-(N-3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl)-Ala-Arg-NH2
-
 ?
alpha1-proteinase inhibitor + H2O MMP-26 cleaves Phe352–Leu353 and Pro357–Met358 in the reactive loop of alpha1-proteinase inhibitor, probably rendering the substrate inactive Homo sapiens ?
-
 ?
insulin-like growth factor-binding protein-1 + H2O cleaves His140–Val141 in insulin-like growth factor-binding protein-1, probably rendering the substrate inactive Homo sapiens ?
-
 ?
peptide + H2O the optimal cleavage motifs for MMP-26 are Lys-Pro-Ile(Leu)-Ser-/-Leu(Met)-Ile(Thr)-Ser(Ala)-Ser. The strongest preference is observed at the P1' and P2 sites where hydrophobic residues are favored. Proline is preferred at P3, and serine is preferred at P1 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
MMP-26
-
 Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00000036
-
 N-[(2R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl]-L-tryptophan
-
 Homo sapiens
0.0000015
-
 (3R)-N-hydroxy-2-[(4-methoxyphenyl)sulfonyl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide
-
 Homo sapiens
0.0000029
-
 4-Aminobenzoyl-Gly-Pro-D-Leu-D-Ala-NHOH
-
 Homo sapiens
0.00006
-
 (3S)-N-hydroxy-2-[(4-methoxyphenyl)sulfonyl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0034
-
-
 Homo sapiens 4-Aminobenzoyl-Gly-Pro-D-Leu-D-Ala-NHOH