Any feedback?
Literature summary for 3.4.24.B7 extracted from
- Unconventional activation mechanisms of MMP-26, a human matrix metalloproteinase with a unique PHCGXXD cysteine-switch motif (2002), J. Biol. Chem., 277, 18967-18972.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| H81R | mutation restores the conventional cysteine-switch in the prodomain but fails to induce the cysteine-swich activation | Homo sapiens |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Zn2+ | zinc ion in the catalytic domain interacts with the conserved sequence PRCXXPD | Homo sapiens |  |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 28000 | - |
x * 28000, proform, SDS-PAGE | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| proteins + H2O | Homo sapiens | - |
peptides | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
enzyme proform contains a unique cystene switch sequence Pro-His81-Cys-Gly-Xaa-Xaa-Asp | - |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| additional information | no activation of the proform by organomercurial treatment | Homo sapiens |
| proteolytic modification | autoactivation by autocleavage of the proform at sequence Lys-Lys-Gln59-Gln60-Phe-His, His81 plays a significant role in functional modification | Homo sapiens |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| proteolytic degradation of proteins | mechanism, His81 plays a significant role in functional modification | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (7-methoxycoumarin-4-yl)acetyl-PLGL-Dpa-AR-NH2 + H2O | synthetic fluorogenic peptide | Homo sapiens | ? | - |
? | |
| proteins + H2O | - |
Homo sapiens | peptides | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 28000, proform, SDS-PAGE | Homo sapiens |
| More | structure modeling | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| M10.029 | Merops-ID | Homo sapiens |
| MMP-26 | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
