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Literature summary for 3.4.24.B6 extracted from

  • Shin, M.; Hu, Y.; Tye, C.E.; Guan, X.; Deagle, C.C.; Antone, J.V.; Smith, C.E.; Simmer, J.P.; Bartlett, J.D.
    Matrix metalloproteinase-20 over-expression is detrimental to enamel development: a Mus musculus model (2014), PLoS ONE, 9, e86774.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.B6

Organism

Organism UniProt Comment Textmining
Mus musculus P57748
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Source Tissue

Source Tissue Comment Organism Textmining

Expression

Organism Comment Expression
Mus musculus Mmp20 expression levels must be within a specific range for normal enamel development to occur. Creation of a normally thick enamel layer may occur over a wider range of Mmp20 expression levels, but acquisition of normal enamel hardness has a narrower range additional information

General Information

General Information Comment Organism
physiological function Mmp20 expression levels must be within a specific range for normal enamel development to occur. Creation of a normally thick enamel layer may occur over a wider range of Mmp20 expression levels, but acquisition of normal enamel hardness has a narrower range. Over-expression of Mmp20 results in decreased enamel hardness, this suggests that a balance exists between cleaved and full-length enamel matrix proteins that are essential for formation of a properly hardened enamel layer. High and medium expressing Mmp20 transgenes in a Mmp20 null background have significantly harder and more mineralized enamel than do low transgene expressers. When the high and medium expressing Mmp20 transgenes are present in the wild-type background, the enamel is significantly less well mineralized than normal Mus musculus