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Literature summary for 3.4.24.B6 extracted from

  • Tanimoto, K.; Le, T.; Zhu, L.; Witkowska, H.E.; Robinson, S.; Hall, S.; Hwang, P.; DenBesten, P.; Li, W.
    Reduced amelogenin-MMP20 interactions in Amelogenesis imperfecta (2008), J. Dent. Res., 87, 451-455.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.B6

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli Homo sapiens

Protein Variants

Protein Variants Comment Organism
E227A inactive Homo sapiens
E227A inactive mutant enzyme Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
SYGYEPMGGWLHHQ competive against Mca-KPLGL-Dpa-AR-NH2 Homo sapiens
SYGYETMGGWLHHQ competive against Mca-KPLGL-Dpa-AR-NH2 Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
55000
-
 SDS-PAGE Homo sapiens
55000
-
 x * 55000, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
amelogenin + H2O Homo sapiens amelogenin with a proline 41 to threonine mutation is hydrolyzed at a lower rate by matrix metalloproteinase 20 (MMP20), resulting in an inherited tooth enamel defect, amelogenesis ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Homo sapiens O60882
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens
recombinant wild-type and inactive mutant E227A Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
amelogenin + H2O cleaves amelogenin between Trp45 and Leu46 Homo sapiens 23 kDa amelogenin + 5 kDa tyrosine-rich amelogenin peptide
-
 ?
amelogenin + H2O amelogenin with a proline 41 to threonine mutation is hydrolyzed at a lower rate by matrix metalloproteinase 20 (MMP20), resulting in an inherited tooth enamel defect, amelogenesis Homo sapiens ?
-
 ?
amelogenin + H2O amelogenin with a proline 41 to threonine mutation is hydrolyzed at a lower rate by matrix metalloproteinase 20 (MMP20), resulting in an inherited tooth enamel defect, amelogenesis imperfecta. P41T mutation reduces the interactions between amelogenin and MMP20, leading to decreased degradation of amelogenin by MMP20, and resulting in amelogenesis imperfecta Homo sapiens ?
-
 ?
Mca-KPLGL-Dpa-AR-NH2 + H2O
-
 Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
? x * 55000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
matrix metalloproteinase 20
-
 Homo sapiens
MMP20
-
 Homo sapiens