Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Collagen | enhances MMP-2 activation by MT2-MMP | Homo sapiens | |
additional information | TIMPs 1-4 and claudin-5 do not enhance MMP-2 activation by MT2-MMP | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli and in Timp2-/- skin fibroblasts | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
TIMP-2 | inhibitory above 10 nM | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
31400 | - |
recombinant form of the MT2-MMP hemopexin C domain with linker | Homo sapiens |
66000 | - |
fully active enzyme, SDS-PAGE | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
Ni2+-chelate column chromatography, CM-Sepharose column chromatography, and Q Sepharose column cromatography | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
pro-form of matrix metalloproteinase 2 + H2O | MMP-2 hemopexin carboxyl domain-dependent activation process | Homo sapiens | active form of matrix metalloproteinase 2 | - |
? | |
Type I collagen + H2O | weak collagenase activity | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
membrane type 2 matrix metalloproteinase | - |
Homo sapiens |
MMP-15 | - |
Homo sapiens |
MT2-MMP | - |
Homo sapiens |