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Literature summary for 3.4.24.B3 extracted from
- Cancer cells, adipocytes and matrix metalloproteinase 11: a vicious tumor progression cycle (2008), Biol. Chem., 389, 1037-1041.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | adipocytes/pre-adipocytes and MMP-11 participate in a highly complex vicious cycle to support tumor progression, and this process is orchestrated by cancer cells. First, both invasive cancer cells and resting adipocytes/pre-adipocytes do not express MMP-11. When a cancer cell meets an adipocyte/pre-adipocyte, their cross-talk/interaction induces the expression/secretion of MMP-11 by the adipocyte/pre-adipocyte. MMP-11 negatively regulates adipogenesis, leading to a decrease in adipocyte differentiation and accumulation/maintenance of MMP-11-expressing fibroblast like cells. These latter cells then act on adjacent invasive cancer cells to favor their survival and potentiate this vicious cycle | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| carcinoma cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | adipocytes/pre-adipocytes and MMP-11 participate in a highly complex vicious cycle to support tumor progression, and this process is orchestrated by cancer cells. First, both invasive cancer cells and resting adipocytes/pre-adipocytes do not express MMP-11. When a cancer cell meets an adipocyte/pre-adipocyte, their cross-talk/interaction induces the expression/secretion of MMP-11 by the adipocyte/pre-adipocyte. MMP-11 negatively regulates adipogenesis, leading to a decrease in adipocyte differentiation and accumulation/maintenance of MMP-11-expressing fibroblast like cells. These latter cells then act on adjacent invasive cancer cells to favor their survival and potentiate this vicious cycle | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| matrix metalloproteinase 11 | - |
Homo sapiens |
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