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Literature summary for 3.4.24.B3 extracted from

  • Amano, T.; Kwak, O.; Fu, L.; Marshak, A.; Shi, Y.B.
    The matrix metalloproteinase stromelysin-3 cleaves laminin receptor at two distinct sites between the transmembrane domain and laminin binding sequence within the extracellular domain (2005), Cell Res., 15, 150-159.
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
laminin receptor precursor + H2O Xenopus laevis laminin receptor precursor is a likely in vivo substrate of stromelysin-3. Its cleavage may alter cell-extracellular matrix interaction, thus playing a role in mediating the effects of stromelysin-3 on cell fate and behavior observed during development and pathogenesis. Human laminin receptor precursor is cleaved by stromelysin-3 at the same two sites as in Xenopus laminin receptor precursor, yielding two N-terminal fragments of sizes identical to the corresponding Xenopus laminin receptor precursor fragments due to amino acid insertion in the C-terminus part of Xenopus laminin receptor precursor ?
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Organism

Organism UniProt Comment Textmining
Xenopus laevis
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Source Tissue

Source Tissue Comment Organism Textmining
carcinoma cell high level Xenopus laevis
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
laminin receptor precursor + H2O
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 Xenopus laevis ?
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laminin receptor precursor + H2O laminin receptor precursor is a likely in vivo substrate of stromelysin-3. Its cleavage may alter cell-extracellular matrix interaction, thus playing a role in mediating the effects of stromelysin-3 on cell fate and behavior observed during development and pathogenesis. Human laminin receptor precursor is cleaved by stromelysin-3 at the same two sites as in Xenopus laminin receptor precursor, yielding two N-terminal fragments of sizes identical to the corresponding Xenopus laminin receptor precursor fragments due to amino acid insertion in the C-terminus part of Xenopus laminin receptor precursor Xenopus laevis ?
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