Literature summary for 3.4.24.B28 extracted from

Lee, H.D.; Koo, B.H.; Kim, Y.H.; Jeon, O.H.; Kim, D.S.
Exosome release of ADAM15 and the functional implications of human macrophage-derived ADAM15 exosomes (2012), FASEB J., 26, 3084-3095.

Search for more literature for 3.4.24.B28

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
exosome	-	Homo sapiens	-	-
extracellular	-	Homo sapiens	-	-
plasma membrane	-	Homo sapiens	5886	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q13444	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
macrophage	-	Homo sapiens	-
THP-1 cell	-	Homo sapiens	-

General Information

General Information	Comment	Organism
physiological function	exosomes rich in ADAM15 display enhanced binding affinity for integrin alpha/beta3 in an Arg-Gly-Asp-dependent manner and suppress vitronectin- and fibronectin-induced cell adhesion, growth, and migration, as well as in vivo tumor growth. Exosomal ADAM15 is released from human macrophages, and macrophage-derived ADAM15 exosomes have tumor inhibitory effects	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)