Literature summary for 3.4.24.B28 extracted from

Boehm, B.B.; Freund, I.; Krause, K.; Kinne, R.W.; Burkhardt, H.
ADAM15 adds to apoptosis resistance of synovial fibroblasts by modulating focal adhesion kinase signaling (2013), Arthritis Rheumatol., 65, 2826-2834.

Search for more literature for 3.4.24.B28

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q13444	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
synovial fibroblast	-	Homo sapiens	-
synovial membrane	-	Homo sapiens	-

Expression

Organism	Comment	Expression
Homo sapiens	the enzyme is up-regulated in the rheumatoid arthritis synovial membrane	up

General Information

General Information	Comment	Organism
malfunction	rheumatoid arthritis synovial fibroblasts display significantly higher caspase 3/7 activity upon camptothecin and FasL exposure when ADAM15 is down-regulated by specific small interfering RNAs. There is also a marked reduction of apoptosis upon knockdown of ADAM15 protein expression	Homo sapiens
physiological function	the enzyme contributes to apoptosis resistance in rheumatoid arthritis synovial fibroblasts by activating the Src/focal adhesion kinase pathway upon FasL exposure	Homo sapiens

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Release 2023.1 (January 2023)