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Literature summary for 3.4.24.B20 extracted from

  • Tanveer, A.; Allen, S.M.; Jackson, K.E.; Charan, M.; Ralph, S.A.; Habib, S.
    An FtsH protease is recruited to the mitochondrion of Plasmodium falciparum (2013), PLoS ONE, 8, e74408.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.B20

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli C41(DE3) cells Plasmodium falciparum

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion inner mitochondrial membrane Plasmodium falciparum 5739
-

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ dependen on Plasmodium falciparum

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
66000
-
 6 * 66000, isoform FtsH1, calculated from amino acid sequence Plasmodium falciparum
104000
-
 6 * 104000, GST-tagged FtsH1, SDS-PAGE Plasmodium falciparum
450000
-
 gel filtration Plasmodium falciparum

Organism

Organism UniProt Comment Textmining
Plasmodium falciparum
-
-
-

Purification (Commentary)

Purification (Comment) Organism
glutathione agarose column chromatography and Ni-NTA column chromatography Plasmodium falciparum

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
alpha-casein + H2O ATP is required for the reaction. The enzyme is unable to degrade the substrate in the presence of AMPPNP Plasmodium falciparum ?
-
 ?

Subunits

Subunits Comment Organism
homohexamer 6 * 104000, GST-tagged FtsH1, SDS-PAGE Plasmodium falciparum
homohexamer 6 * 66000, isoform FtsH1, calculated from amino acid sequence Plasmodium falciparum

Synonyms

Synonyms Comment Organism
FtsH1
-
 Plasmodium falciparum

Cofactor

Cofactor Comment Organism Structure
ATP required for activity Plasmodium falciparum

General Information

General Information Comment Organism
physiological function FtsH1 is a regulatory protein for organelle biogenesis in Plasmodium falciparum Plasmodium falciparum