Activating Compound | Comment | Organism | Structure |
---|---|---|---|
ATP | dependent on | Spinacia oleracea | |
ATP | dependent on | Synechocystis sp. | |
ATP | dependent on | Escherichia coli | |
ATP | dependent on | Arabidopsis thaliana |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
chloroplast | - |
Spinacia oleracea | 9507 | - |
chloroplast | - |
Synechocystis sp. | 9507 | - |
chloroplast | - |
Arabidopsis thaliana | 9507 | - |
mitochondrion | - |
Arabidopsis thaliana | 5739 | - |
thylakoid membrane | - |
Synechocystis sp. | 42651 | - |
thylakoid membrane | - |
Arabidopsis thaliana | 42651 | - |
thylakoid membrane | mostly of stroma thylakoids | Spinacia oleracea | 42651 | - |
thylakoid membrane | VAR1 forms complexes with VAR2 | Arabidopsis thaliana | 42651 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | dependent on | Spinacia oleracea | |
Zn2+ | dependent on | Synechocystis sp. | |
Zn2+ | dependent on | Arabidopsis thaliana | |
Zn2+ | dependent on, zinc metallopeptidase | Escherichia coli |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
67250 | - |
x * 68199, sll1463, sequence calculation, x * 68496, slr0228, sequence calculation, x * 67250, slr1640, sequence calculation, x * 69304, slr1390, sequence calculation | Synechocystis sp. |
68199 | - |
x * 68199, sll1463, sequence calculation, x * 68496, slr0228, sequence calculation, x * 67250, slr1640, sequence calculation, x * 69304, slr1390, sequence calculation | Synechocystis sp. |
68496 | - |
x * 68199, sll1463, sequence calculation, x * 68496, slr0228, sequence calculation, x * 67250, slr1640, sequence calculation, x * 69304, slr1390, sequence calculation | Synechocystis sp. |
69304 | - |
x * 68199, sll1463, sequence calculation, x * 68496, slr0228, sequence calculation, x * 67250, slr1640, sequence calculation, x * 69304, slr1390, sequence calculation | Synechocystis sp. |
70709 | - |
x * 70709, sequence calculation | Escherichia coli |
73198 | - |
x * 73198, FtsH8, sequence calculation | Arabidopsis thaliana |
74515 | - |
x * 74515, FtsH6, sequence calculation | Arabidopsis thaliana |
75232 | - |
x * 75232, FtsH5, sequence calculation | Arabidopsis thaliana |
76759 | - |
x * 76759, FtsH1, sequence calculation | Arabidopsis thaliana |
77275 | - |
x * 77275, FtsH4, sequence calculation | Arabidopsis thaliana |
87802 | - |
x * 87802, FtsH7, sequence calculation | Arabidopsis thaliana |
87838 | - |
x * 87838, FtsH9, sequence calculation | Arabidopsis thaliana |
88717 | - |
x * 88717, FtsH11, sequence calculation | Arabidopsis thaliana |
89353 | - |
x * 89353, FtsH3, sequence calculation | Arabidopsis thaliana |
89555 | - |
x * 89555, FtsH10, sequence calculation | Arabidopsis thaliana |
115105 | - |
x * 115105, FtsH12, sequence calculation | Arabidopsis thaliana |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
damaged PSII D1 protein + H2O | Spinacia oleracea | - |
? | - |
? | |
damaged PSII D1 protein + H2O | Synechocystis sp. | - |
? | - |
? | |
damaged PSII D1 protein + H2O | Escherichia coli | - |
? | - |
? | |
damaged PSII D1 protein + H2O | Arabidopsis thaliana | - |
? | - |
? | |
additional information | Escherichia coli | FtsH is complexed with HflCK | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Arabidopsis thaliana | O80860 | FtsH2 or VAR2; 12 FtsH genes | - |
Arabidopsis thaliana | O80983 | FtsH4; 12 FtsH genes | - |
Arabidopsis thaliana | Q1PDW5 | FtsH6; 12 FtsH genes | - |
Arabidopsis thaliana | Q39102 | FtsH1; 12 FtsH genes | - |
Arabidopsis thaliana | Q84WU8 | FtsH3; 12 FtsH genes | - |
Arabidopsis thaliana | Q8VZI8 | FtsH10 or FtsHA; 12 FtsH genes | - |
Arabidopsis thaliana | Q8W585 | FtsH8; 12 FtsH genes | - |
Arabidopsis thaliana | Q9FGM0 | FtsH11 or FtsHB; 12 FtsH genes | - |
Arabidopsis thaliana | Q9FH02 | FtsH5 or VAR1; 12 FtsH genes | - |
Arabidopsis thaliana | Q9FIM2 | FtsH9; 12 FtsH genes | - |
Arabidopsis thaliana | Q9SAJ3 | FtsH12 or FtsHC; 12 FtsH genes | - |
Arabidopsis thaliana | Q9SD67 | FtsH7; 12 FtsH genes | - |
Escherichia coli | P0AAI3 | - |
- |
Spinacia oleracea | - |
- |
- |
Synechocystis sp. | - |
genes slr0228, sll1463, slr1390, and slr1640 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
leaf | - |
Spinacia oleracea | - |
leaf | - |
Arabidopsis thaliana | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
damaged PSII D1 protein + H2O | - |
Spinacia oleracea | ? | - |
? | |
damaged PSII D1 protein + H2O | - |
Synechocystis sp. | ? | - |
? | |
damaged PSII D1 protein + H2O | - |
Escherichia coli | ? | - |
? | |
damaged PSII D1 protein + H2O | - |
Arabidopsis thaliana | ? | - |
? | |
additional information | FtsH is complexed with HflCK | Escherichia coli | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 115105, FtsH12, sequence calculation | Arabidopsis thaliana |
? | x * 68199, sll1463, sequence calculation, x * 68496, slr0228, sequence calculation, x * 67250, slr1640, sequence calculation, x * 69304, slr1390, sequence calculation | Synechocystis sp. |
? | x * 70709, sequence calculation | Escherichia coli |
? | x * 73198, FtsH8, sequence calculation | Arabidopsis thaliana |
? | x * 74515, FtsH6, sequence calculation | Arabidopsis thaliana |
? | x * 75232, FtsH5, sequence calculation | Arabidopsis thaliana |
? | x * 76759, FtsH1, sequence calculation | Arabidopsis thaliana |
? | x * 77275, FtsH4, sequence calculation | Arabidopsis thaliana |
? | x * 87802, FtsH7, sequence calculation | Arabidopsis thaliana |
? | x * 87838, FtsH9, sequence calculation | Arabidopsis thaliana |
? | x * 88717, FtsH11, sequence calculation | Arabidopsis thaliana |
? | x * 89353, FtsH3, sequence calculation | Arabidopsis thaliana |
? | x * 89555, FtsH10, sequence calculation | Arabidopsis thaliana |
Synonyms | Comment | Organism |
---|---|---|
filamentation temperature sensitive H | - |
Spinacia oleracea |
filamentation temperature sensitive H | - |
Synechocystis sp. |
filamentation temperature sensitive H | - |
Escherichia coli |
filamentation temperature sensitive H | - |
Arabidopsis thaliana |
FtsH | - |
Spinacia oleracea |
FtsH | - |
Synechocystis sp. |
FtsH | - |
Escherichia coli |
FtsH | - |
Arabidopsis thaliana |
HflB | - |
Escherichia coli |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
assay at | Spinacia oleracea |
Organism | Comment | pI Value Maximum | pI Value |
---|---|---|---|
Synechocystis sp. | slr1640, sequence calculation | - |
5.11 |
Synechocystis sp. | slr1390, sequence calculation | - |
5.23 |
Synechocystis sp. | slr0228, sequence calculation | - |
5.29 |
Synechocystis sp. | sll1463, sequence calculation | - |
5.31 |
Arabidopsis thaliana | FtsH5, sequence calculation | - |
5.37 |
Arabidopsis thaliana | FtsH1, sequence calculation | - |
5.64 |
Arabidopsis thaliana | FtsH8, sequence calculation | - |
5.72 |
Arabidopsis thaliana | FtsH11, sequence calculation | - |
5.8 |
Escherichia coli | sequence calculation | - |
5.91 |
Arabidopsis thaliana | FtsH2, sequence calculation | - |
5.99 |
Arabidopsis thaliana | FtsH12, sequence calculation | - |
6.49 |
Arabidopsis thaliana | FtsH3, sequence calculation | - |
6.8 |
Arabidopsis thaliana | FtsH6, sequence calculation | - |
7.21 |
Arabidopsis thaliana | FtsH9, sequence calculation | - |
7.66 |
Arabidopsis thaliana | FtsH7, sequence calculation | - |
8.3 |
Arabidopsis thaliana | FtsH10, sequence calculation | - |
8.44 |
Arabidopsis thaliana | FtsH4, sequence calculation | - |
8.73 |
General Information | Comment | Organism |
---|---|---|
evolution | the mode of action of FtsH proteases seems to be different between cyanobacteria and higher plants | Spinacia oleracea |
metabolism | enzyme regulation, overview | Spinacia oleracea |
metabolism | enzyme regulation, overview | Synechocystis sp. |
metabolism | enzyme regulation, overview | Escherichia coli |
metabolism | enzyme regulation, overview | Arabidopsis thaliana |
physiological function | FtsH is a membrane-bound protein essential for the cell viability in Escherichia coli | Escherichia coli |
physiological function | the ATP-dependent metalloprotease FtsH is involved in the degradation of the photo- or heat-damaged D1 protein. Damage occurs in the reaction center-binding D1 protein understrong visible light and heat stress, overview | Spinacia oleracea |
physiological function | the ATP-dependent zinc metallopeptidase is a cell division protein | Synechocystis sp. |
physiological function | the ATP-dependent zinc metallopeptidase is a cell division protein | Arabidopsis thaliana |
physiological function | the ATP-dependent zinc metallopeptidase is a cell division protein. FtsH2 and FtsH5 are responsible for leaf variegation and proteolysis of photodamaged D1 protein in Arabidopsis | Arabidopsis thaliana |
physiological function | the ATP-dependent zinc metallopeptidase is involved in the degradation of both Lhcb3 and Lhcb1 during senescence and high-light acclimation | Arabidopsis thaliana |
physiological function | the ATP-dependent zinc metallopeptidase is involved in the repair of PSII following damage incurred during photoinhibition. FtsH2 and FtsH5 are responsible for leaf variegation and proteolysis of photodamaged D1 protein in Arabidopsis | Arabidopsis thaliana |