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Literature summary for 3.4.24.B20 extracted from

  • Le, A.T.; Schumann, W.
    The Spo0E phosphatase of Bacillus subtilis is a substrate of the FtsH metalloprotease (2009), Microbiology, 155, 1122-1132.
    View publication on PubMed
Search for more literature for 3.4.24.B20

Activating Compound

Activating Compound Comment Organism Structure
ATP dependent on Bacillus subtilis

Cloned(Commentary)

Cloned (Comment) Organism
expression of GST-tagged wild-type and mutant enzymes in Escherichia coli ftsh-deficient strain A8296 Bacillus subtilis

Protein Variants

Protein Variants Comment Organism
additional information generation of ftsH knockouts, that show a sporulation frequency reduced by several orders of magnitude. The combination of ftsH knockout with knockout of one of the phosphatases RapA, RapB, RapE or Spo0E results in a sporulation frequency, that is increased by two to three orders of magnitude, but still remains below 1% of wild-type level, overview Bacillus subtilis

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ a metalloprotease Bacillus subtilis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Spo0E + H2O Bacillus subtilis the Spo0E phosphatase is distinguished from the YisI and YnzD phosphatases by a C-terminal extension of about 25 amino acids, the C-terminal region of Spo0E confers target specificity to FtsH ?
-
 ?

Organism

Organism UniProt Comment Textmining
Bacillus subtilis
-
 gene ftsH
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information neither phosphatases YisI nor YnzD, homologues of Spo0E, are substrates of FtsH Bacillus subtilis ?
-
 ?
Spo0E + H2O
-
 Bacillus subtilis ?
-
 ?
Spo0E + H2O the Spo0E phosphatase is distinguished from the YisI and YnzD phosphatases by a C-terminal extension of about 25 amino acids, the C-terminal region of Spo0E confers target specificity to FtsH Bacillus subtilis ?
-
 ?

Synonyms

Synonyms Comment Organism
FtsH metalloprotease
-
 Bacillus subtilis

Expression

Organism Comment Expression
Bacillus subtilis phosphatases RapA, RapB, RapE and Spo0E are negative regulators of FtsH down

General Information

General Information Comment Organism
additional information ftsH interferes with the expression or activity of phosphatases RapA, RapB, RapE and Spo0E, and interferes with the phosphorylation status of Spo0A through Spo0E Bacillus subtilis
physiological function FtsH has to degrade or to regulate the steady-state level of one or more proteins that interfere with successful sporulation. In the absence of the ATP-dependent metalloprotease FtsH, the sporulation frequency of Bacillus subtilis cells is reduced by several orders of magnitude Bacillus subtilis